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Mecasermin Side Effects

The most commonly reported side effects of mecasermin include off label use, headache, and fatigue, based on 1,319 FDA adverse event reports from 2004 to 2025. 2.8% of reports found the drug to be ineffective.

Mecasermin side effects

Percentages show how often each reaction appears relative to total reports for mecasermin.

1
Off Label Use10.4%137
2
Headache4.2%56
3
Fatigue3.6%48
4
Pyrexia3.0%40
5
Hypoglycaemia3.0%40
6
Drug Dose Omission2.9%38
7
Drug Ineffective2.8%37
8
Vomiting2.7%36
9
Injection Site Pain2.7%36
10
Blood Glucose Decreased2.5%33
11
Headache2.3%30
12
Product Dose Omission Issue2.2%29
13
Decreased Appetite2.1%28
14
Tonsillar Hypertrophy2.0%27
15
Nausea2.0%26

These are voluntary reports and do not establish that mecasermin caused these reactions.

Report severity

66.0%Serious871 reports
36.3%Hospitalizations479 reports
7.2%Fatal95 reports

Seriousness is determined by the reporter, not by OpenClaim.

Mecasermin drug interactions

Other drugs that appear in adverse event reports alongside mecasermin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Paclitaxel2.5%33
2
Methylprednisolone2.5%33
3
Omeprazole1.5%20
4
Carboplatin1.4%19
5
Dexchlorpheniramine-maleate1.4%19
6
Somatropin1.4%18
7
Lenalidomide1.3%17
8
Clavulanate-potassium1.2%16
9
Amoxicillin1.2%16
10
Dexamethasone1.1%15
11
Vancomycin1.1%14
12
Adalimumab1.1%14
13
Bevacizumab1.0%13
14
Prednisone0.9%12
15
Metformin0.9%12

Taken alongside

1
Levothyroxine-sodium6.7%89
2
Acetaminophen6.6%87
3
Omeprazole4.9%64
4
Ergocalciferol4.7%62
5
Albuterol4.2%56
6
Aspirin3.3%44
7
Amlodipine3.3%43
8
Metformin3.1%41
9
Hydroxyzine3.0%40
10
Dexchlorpheniramine-maleate3.0%39
11
Insulin3.0%39
12
Prednisone2.7%36
13
Ondansetron2.7%36
14
Gabapentin2.7%36
15
Atorvastatin-calcium2.5%33

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports mecasermin side effects

37.8% of mecasermin adverse event reports involve female patients and 56.7% involve male patients. The largest age group is child at 33%. These figures reflect who reports side effects, not underlying risk.

Sex

Female37.8%
Male56.7%
Unknown5.5%

Age group

< 22.8%
2–1133.2%
12–1723.9%
18–6421.6%
65+18.5%

What is mecasermin used for

Conditions and purposes for which patients were taking mecasermin when the adverse event was reported.

Abdominal Pain UpperAcneAcquired Growth Hormone ResistanceAmyotrophic Lateral SclerosisAnaesthesiaAnaesthetic PremedicationAndrogen Insensitivity SyndromeAntibody Test PositiveAnticoagulant TherapyArterial Therapeutic ProcedureAutosomal Chromosome AnomalyAcquired Growth Hormone ResistanceAcute Myeloid LeukaemiaBehaviour DisorderBiliary Cirrhosis

Showing 15 of 161 indications

Mecasermin brand names and reporting trend

Mecasermin is sold under the brand name Iplex.

Brand names

Iplex28

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking mecasermin with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.