OpenClaim

Mavacamten Side Effects

The most commonly reported side effects of mavacamten include product dose omission issue, atrial fibrillation, and fatigue, based on 3,708 FDA adverse event reports from 2022 to 2025.

Mavacamten side effects

Percentages show how often each reaction appears relative to total reports for mavacamten.

1
Product Dose Omission Issue7.0%260
2
Atrial Fibrillation6.7%250
3
Fatigue6.5%240
4
Dyspnoea6.3%233
5
Dizziness6.1%227
6
Product Use Issue5.2%191
7
Off Label Use3.9%144
8
Ejection Fraction Decreased3.5%131
9
Nasopharyngitis3.2%118
10
Headache3.2%118
11
Adverse Event2.9%109
12
Palpitations2.8%102
13
Chest Pain2.6%98
14
Weight Increased2.4%88
15
Cough2.3%86

These are voluntary reports and do not establish that mavacamten caused these reactions.

Report severity

38.6%Serious1,432 reports
14.6%Hospitalizations543 reports
2.5%Fatal92 reports

Seriousness is determined by the reporter, not by OpenClaim.

Mavacamten drug interactions

Other drugs that appear in adverse event reports alongside mavacamten. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Apixaban0.8%28
2
Dupilumab0.6%23
3
Metoprolol0.6%22
4
Amlodipine0.4%15
5
Verapamil-hydrochloride0.3%12
6
Amiodarone-hydrochloride0.3%12
7
Bisoprolol-fumarate0.3%11
8
Disopyramide-phosphate0.3%10
9
Semaglutide0.2%9
10
Spironolactone0.2%9
11
Omeprazole0.2%8
12
Diltiazem0.2%7
13
Famotidine0.2%7
14
Rosuvastatin0.2%7
15
Atorvastatin-calcium0.2%6

Taken alongside

1
Metoprolol13.5%501
2
Aspirin7.4%274
3
Ergocalciferol7.3%270
4
Atorvastatin-calcium7.0%258
5
Acetaminophen6.1%225
6
Apixaban5.4%201
7
Rosuvastatin5.1%188
8
Furosemide4.9%182
9
Pantoprazole-sodium4.7%176
10
Levothyroxine-sodium4.7%175
11
Albuterol3.5%130
12
Ascorbic-acid3.4%125
13
Cyanocobalamin3.1%116
14
Fluticasone3.0%111
15
Verapamil-hydrochloride2.9%108

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports mavacamten side effects

58.3% of mavacamten adverse event reports involve female patients and 26.3% involve male patients. The largest age group is elderly at 63%. These figures reflect who reports side effects, not underlying risk.

Sex

Female58.3%
Male26.3%
Unknown15.4%

Age group

< 2<0.1%
2–110.1%
12–170.1%
18–6436.6%
65+63.1%

What is mavacamten used for

Conditions and purposes for which patients were taking mavacamten when the adverse event was reported.

Angina PectorisAortic StenosisAortic Valve IncompetenceArteriosclerosis Coronary ArteryAtrial FibrillationBehaviour DisorderCardiac DisorderCardiac FailureCardiac Failure CongestiveCardiac HypertrophyCardiac MurmurCardiac Valve DiseaseCardiac Ventricular DisorderCardiomegalyCardiomyopathy

Showing 15 of 39 indications

Mavacamten brand names and reporting trend

Mavacamten is sold under the brand name Camzyos.

Brand names

Camzyos283

Quarterly reports (20222025)

202220242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking mavacamten with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.