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Margetuximab Side Effects

The most commonly reported side effects of margetuximab include disease progression, dry gangrene, and nausea, based on 65 FDA adverse event reports from 2021 to 2025. 10.8% of reports found the drug to be ineffective.

Margetuximab side effects

Percentages show how often each reaction appears relative to total reports for margetuximab.

1
Disease Progression16.9%11
2
Dry Gangrene10.8%7
3
Drug Ineffective10.8%7
4
Nausea7.7%5
5
Diarrhoea7.7%5
6
Death7.7%5
7
Ischaemia7.7%5
8
Fatigue6.2%4
9
Peripheral Ischaemia6.2%4
10
Thrombocytopenia4.6%3
11
Vomiting4.6%3
12
Decreased Appetite4.6%3
13
Alanine Aminotransferase Increased4.6%3
14
Neuropathy Peripheral4.6%3
15
Constipation4.6%3

These are voluntary reports and do not establish that margetuximab caused these reactions.

Report severity

73.8%Serious48 reports
44.6%Hospitalizations29 reports
15.4%Fatal10 reports

Seriousness is determined by the reporter, not by OpenClaim.

Margetuximab drug interactions

Other drugs that appear in adverse event reports alongside margetuximab. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Trastuzumab21.5%14
2
Gemcitabine20.0%13
3
Retifanlimab-dlwr13.8%9
4
Capecitabine12.3%8
5
Pertuzumab9.2%6
6
Vinorelbine-tartrate7.7%5
7
Eribulin-mesylate7.7%5
8
Paclitaxel7.7%5
9
Tucatinib7.7%5
10
Doxorubicin-hydrochloride4.6%3
11
Carboplatin4.6%3
12
Docetaxel4.6%3
13
Gabapentin3.1%2
14
Ibuprofen3.1%2
15
Triamcinolone3.1%2

Taken alongside

1
Trastuzumab15.4%10
2
Diphenhydramine12.3%8
3
Omeprazole10.8%7
4
Eribulin-mesylate10.8%7
5
Capecitabine10.8%7
6
Ondansetron9.2%6
7
Gabapentin7.7%5
8
Gemcitabine7.7%5
9
Vinorelbine-tartrate7.7%5
10
Apixaban6.2%4
11
Acetaminophen6.2%4
12
Ergocalciferol6.2%4
13
Pertuzumab6.2%4
14
Oxaliplatin6.2%4
15
Neratinib-maleate6.2%4

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports margetuximab side effects

75.4% of margetuximab adverse event reports involve female patients and 13.8% involve male patients. The largest age group is adult at 71%. These figures reflect who reports side effects, not underlying risk.

Sex

Female75.4%
Male13.8%
Unknown10.8%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6470.8%
65+29.2%

What is margetuximab used for

Conditions and purposes for which patients were taking margetuximab when the adverse event was reported.

Breast CancerBreast Cancer MetastaticBone CancerBreast CancerBreast Cancer FemaleBreast Cancer MetastaticCholangiocarcinomaChemotherapyColorectal CancerGastric CancerGastric CancerGastrooesophageal CancerHer2 Positive Breast CancerHormone Receptor Negative Her2 Positive Breast CancerHormone Receptor Positive Breast Cancer

Showing 15 of 24 indications

Margetuximab brand names and reporting trend

Margetuximab is sold under the brand name Margenza.

Brand names

Margenza66

Quarterly reports (20212025)

202120222025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking margetuximab with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.