OpenClaim

Maprotiline Side Effects

The most commonly reported side effects of maprotiline include constipation, visual impairment, and off label use, based on 985 FDA adverse event reports from 2004 to 2025. 4.5% of reports found the drug to be ineffective.

Maprotiline side effects

Percentages show how often each reaction appears relative to total reports for maprotiline.

1
Constipation5.4%53
2
Visual Impairment5.0%49
3
Off Label Use4.8%47
4
Mental Disorder4.8%47
5
Tremor4.6%45
6
Tachycardia4.5%44
7
Drug Ineffective4.5%44
8
Dizziness4.4%43
9
Fatigue4.3%42
10
Fall4.3%42
11
Drug Interaction4.2%41
12
Nausea4.1%40
13
Suicidal Ideation4.1%40
14
Depression4.0%39
15
Somnolence3.8%37

These are voluntary reports and do not establish that maprotiline caused these reactions.

Report severity

93.6%Serious922 reports
52.5%Hospitalizations517 reports
11.0%Fatal108 reports

Seriousness is determined by the reporter, not by OpenClaim.

Maprotiline drug interactions

Other drugs that appear in adverse event reports alongside maprotiline. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Duloxetine-hydrochloride11.2%110
2
Mirtazapine10.9%107
3
Clomipramine-hydrochloride8.3%82
4
Quetiapine-fumarate7.4%73
5
Olanzapine6.3%62
6
Amitriptyline-hydrochloride5.8%57
7
Doxepin-hydrochloride5.2%51
8
Risperidone5.0%49
9
Lamotrigine4.6%45
10
Alprazolam4.5%44
11
Venlafaxine4.5%44
12
Lorazepam4.5%44
13
Paroxetine4.4%43
14
Ranitidine4.4%43
15
Aripiprazole4.2%41

Taken alongside

1
Omeprazole8.2%81
2
Diazepam7.7%76
3
Pantoprazole-sodium7.4%73
4
Diclofenac7.1%70
5
Aspirin7.0%69
6
Pregabalin6.5%64
7
Levothyroxine-sodium6.3%62
8
Ramipril5.9%58
9
Clomipramine-hydrochloride5.3%52
10
Amitriptyline-hydrochloride5.1%50
11
Ranitidine4.4%43
12
Ibuprofen4.3%42
13
Magnesium-acetate-tetrahydrate4.1%40
14
Celecoxib4.1%40
15
Alprazolam3.9%38

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports maprotiline side effects

61.3% of maprotiline adverse event reports involve female patients and 32.7% involve male patients. The largest age group is adult at 53%. These figures reflect who reports side effects, not underlying risk.

Sex

Female61.3%
Male32.7%
Unknown6.0%

Age group

< 21.3%
2–110.6%
12–170.9%
18–6453.0%
65+44.1%

What is maprotiline used for

Conditions and purposes for which patients were taking maprotiline when the adverse event was reported.

Accidental Exposure To Product By ChildAffect LabilityAffective DisorderAgitationAnorexia NervosaAntidepressant TherapyAnxietyAttention Deficit/hyperactivity DisorderAutonomic Nervous System ImbalanceAnxiety DisorderBipolar DisorderBipolar I DisorderBipolar Ii DisorderBorderline Personality DisorderBipolar Ii Disorder

Showing 15 of 73 indications

Maprotiline brand names and reporting trend

Maprotiline is sold under the brand name Ludiomil.

Brand names

Ludiomil23

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking maprotiline with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.