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Manganese Sulfate Side Effects

The most commonly reported side effects of manganese sulfate include covid-19, fatigue, and platelet count decreased, based on 249 FDA adverse event reports from 2004 to 2025. 6.4% of reports found the drug to be ineffective.

Manganese Sulfate side effects

Percentages show how often each reaction appears relative to total reports for manganese sulfate.

1
Covid-1914.1%35
2
Fatigue10.0%25
3
Platelet Count Decreased9.6%24
4
Thrombocytopenia9.6%24
5
Respiratory Tract Infection9.6%24
6
Respiratory Tract Infection Viral9.6%24
7
Respiratory Tract Infection Bacterial9.2%23
8
Pulmonary Embolism8.8%22
9
Anaemia8.0%20
10
Nausea7.2%18
11
Intentional Product Use Issue7.2%18
12
Drug Ineffective6.4%16
13
Malaise6.4%16
14
Pyrexia6.0%15
15
Neutropenia6.0%15

These are voluntary reports and do not establish that manganese sulfate caused these reactions.

Report severity

54.6%Serious136 reports
32.9%Hospitalizations82 reports
12.4%Fatal31 reports

Seriousness is determined by the reporter, not by OpenClaim.

Manganese Sulfate drug interactions

Other drugs that appear in adverse event reports alongside manganese sulfate. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Lenalidomide14.9%37
2
Dexamethasone9.6%24
3
Ixazomib-citrate9.6%24
4
Apixaban8.0%20
5
Cyclophosphamide7.6%19
6
Dupilumab5.6%14
7
Palbociclib4.4%11
8
Sodium-oxybate4.0%10
9
Adalimumab3.6%9
10
Zinc-sulfate3.2%8
11
Etanercept3.2%8
12
Nirmatrelvir3.2%8
13
Ritonavir3.2%8
14
Ropeginterferon-alfa-2b-njft2.8%7
15
Enzalutamide2.4%6

Taken alongside

1
Ergocalciferol49.8%124
2
Aspirin31.7%79
3
Ascorbic-acid28.9%72
4
Folic-acid25.3%63
5
Amlodipine22.1%55
6
Metoprolol19.7%49
7
Cyanocobalamin19.3%48
8
Magnesium-acetate-tetrahydrate18.9%47
9
Calcium18.1%45
10
Atorvastatin-calcium17.7%44
11
Magnesium-oxide17.3%43
12
Levothyroxine-sodium16.9%42
13
Acetaminophen14.9%37
14
Calcium-carbonate14.9%37
15
Fluticasone14.5%36

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports manganese sulfate side effects

46.6% of manganese sulfate adverse event reports involve female patients and 43.4% involve male patients. The largest age group is elderly at 63%. These figures reflect who reports side effects, not underlying risk.

Sex

Female46.6%
Male43.4%
Unknown10.0%

Age group

< 21.1%
2–110.0%
12–171.1%
18–6434.9%
65+63.0%

What is manganese sulfate used for

Conditions and purposes for which patients were taking manganese sulfate when the adverse event was reported.

Benign Prostatic HyperplasiaChondropathyDysuriaInflammationMuscle DisorderMalnutritionMineral DeficiencyNauseaNeuropathy PeripheralParenteral NutritionProduct Used For Unknown IndicationProduct Used For Unknown IndicationRoutine Health MaintenanceSupplementation TherapySupplementation Therapy

Manganese Sulfate brand names and reporting trend

Manganese Sulfate is sold under the brand name Tralement.

Brand names

Tralement283

Quarterly reports (20042025)

200420202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking manganese sulfate with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.