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Magnesium Oxybate Side Effects

The most commonly reported side effects of magnesium oxybate include product administration interrupted, surgery, and nausea, based on 8,334 FDA adverse event reports from 2010 to 2025. 4.4% of reports found the drug to be ineffective.

Magnesium Oxybate side effects

Percentages show how often each reaction appears relative to total reports for magnesium oxybate.

1
Product Administration Interrupted17.8%1,480
2
Surgery12.7%1,057
3
Nausea10.5%876
4
Product Dose Omission Issue9.7%810
5
Anxiety7.6%632
6
Intentional Dose Omission6.5%545
7
Intentional Product Use Issue5.8%484
8
Headache5.8%483
9
Dizziness5.6%467
10
Somnolence5.4%448
11
Vomiting4.9%409
12
Feeling Abnormal4.7%394
13
Depression4.7%390
14
Weight Decreased4.5%377
15
Drug Ineffective4.4%368

These are voluntary reports and do not establish that magnesium oxybate caused these reactions.

Report severity

81.5%Serious6,792 reports
19.2%Hospitalizations1,604 reports
2.2%Fatal187 reports

Seriousness is determined by the reporter, not by OpenClaim.

Magnesium Oxybate drug interactions

Other drugs that appear in adverse event reports alongside magnesium oxybate. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Sodium-oxybate94.1%7,840
2
Calcium-oxybate93.5%7,789
3
Potassium-oxybate93.5%7,789
4
Solriamfetol2.2%183
5
Amphetamine2.2%182
6
Dextroamphetamine1.3%107
7
Diazepam1.0%84
8
Sildenafil-citrate0.9%78
9
Alcohol0.9%76
10
Modafinil0.8%67
11
Cocaine-hydrochloride0.8%66
12
Methylphenidate0.8%63
13
Oxycodone0.7%56
14
Tramadol-hydrochloride0.7%55
15
Acetaminophen0.6%54

Taken alongside

1
Dextroamphetamine14.0%1,163
2
Amphetamine12.6%1,051
3
Ergocalciferol11.6%967
4
Acetaminophen8.9%739
5
Albuterol8.7%726
6
Fluticasone8.5%706
7
Modafinil8.0%666
8
Levothyroxine-sodium7.6%631
9
Gabapentin7.2%596
10
Armodafinil7.0%585
11
Omeprazole6.7%559
12
Methylphenidate6.6%552
13
Bupropion6.4%531
14
Ondansetron6.3%522
15
Solriamfetol5.9%490

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports magnesium oxybate side effects

68.4% of magnesium oxybate adverse event reports involve female patients and 27.9% involve male patients. The largest age group is adult at 86%. These figures reflect who reports side effects, not underlying risk.

Sex

Female68.4%
Male27.9%
Unknown3.6%

Age group

< 20.3%
2–110.6%
12–173.1%
18–6486.1%
65+9.8%

What is magnesium oxybate used for

Conditions and purposes for which patients were taking magnesium oxybate when the adverse event was reported.

Accidental Exposure To ProductAnxiolytic TherapyAutism Spectrum DisorderBradycardiaBradypnoeaCataplexyCataplexyCentral Sleep Apnoea SyndromeChronic Fatigue SyndromeCircadian Rhythm Sleep DisorderCystitis InterstitialDelayed Sleep PhaseDepressionDrug AbuseDrug Withdrawal Syndrome

Showing 15 of 52 indications

Magnesium Oxybate brand names and reporting trend

Magnesium Oxybate is sold under the brand name Xywav.

Brand names

Xywav445

Quarterly reports (20102025)

2010202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking magnesium oxybate with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.