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Magnesium Oxide Side Effects

The most commonly reported side effects of magnesium oxide include nausea, diarrhoea, and fatigue, based on 42,873 FDA adverse event reports from 2004 to 2025. 4.0% of reports found the drug to be ineffective.

Magnesium Oxide side effects

Percentages show how often each reaction appears relative to total reports for magnesium oxide.

1
Nausea6.2%2,655
2
Diarrhoea5.8%2,479
3
Fatigue5.3%2,279
4
Off Label Use4.6%1,961
5
Dyspnoea4.3%1,856
6
Pneumonia4.1%1,770
7
Drug Ineffective4.0%1,700
8
Vomiting3.7%1,599
9
Headache3.7%1,570
10
Pyrexia3.6%1,528
11
Death3.5%1,507
12
Pain3.1%1,335
13
Constipation3.1%1,321
14
Decreased Appetite3.0%1,307
15
Anaemia2.9%1,249

These are voluntary reports and do not establish that magnesium oxide caused these reactions.

Report severity

79.2%Serious33,954 reports
48.9%Hospitalizations20,981 reports
15.5%Fatal6,657 reports

Seriousness is determined by the reporter, not by OpenClaim.

Magnesium Oxide drug interactions

Other drugs that appear in adverse event reports alongside magnesium oxide. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Lenalidomide6.0%2,591
2
Sodium-oxybate4.1%1,761
3
Sodium-picosulfate2.9%1,257
4
Citric-acid2.7%1,178
5
Prednisone2.4%1,030
6
Pantoprazole-sodium2.1%891
7
Nivolumab2.1%883
8
Adalimumab2.0%871
9
Treprostinil2.0%861
10
Apixaban1.8%786
11
Dexamethasone1.8%758
12
Aspirin1.7%745
13
Paclitaxel1.7%738
14
Pomalidomide1.7%726
15
Pembrolizumab1.7%717

Taken alongside

1
Ergocalciferol21.8%9,353
2
Aspirin21.8%9,336
3
Acetaminophen21.5%9,233
4
Furosemide18.5%7,911
5
Amlodipine15.9%6,820
6
Omeprazole14.3%6,145
7
Levothyroxine-sodium13.4%5,753
8
Atorvastatin-calcium13.3%5,686
9
Potassium-chloride13.0%5,574
10
Metoprolol12.8%5,470
11
Gabapentin11.9%5,120
12
Ondansetron11.7%5,033
13
Pantoprazole-sodium11.6%4,972
14
Albuterol11.5%4,939
15
Prednisone11.3%4,846

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports magnesium oxide side effects

52.6% of magnesium oxide adverse event reports involve female patients and 40.9% involve male patients. The largest age group is elderly at 60%. These figures reflect who reports side effects, not underlying risk.

Sex

Female52.6%
Male40.9%
Unknown6.5%

Age group

< 20.2%
2–110.5%
12–170.8%
18–6439.0%
65+59.5%

What is magnesium oxide used for

Conditions and purposes for which patients were taking magnesium oxide when the adverse event was reported.

Abdominal DiscomfortAbdominal DistensionAbdominal PainAbdominal Pain LowerAbdominal Pain UpperAbdominal SymptomAbnormal FaecesAcidosisAcute Myeloid LeukaemiaAcute Myocardial InfarctionAdenocarcinoma PancreasAdjuvant TherapyAdverse Drug ReactionAdverse EventAdverse Reaction

Showing 15 of 575 indications

Magnesium Oxide brand names and reporting trend

Magnesium Oxide is sold under the brand name Clenpiq.

Brand names

Clenpiq44,908

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking magnesium oxide with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.