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Magnesium Hydroxide Side Effects

The most commonly reported side effects of magnesium hydroxide include chronic kidney disease, acute kidney injury, and constipation, based on 10,339 FDA adverse event reports from 2004 to 2025. 6.4% of reports found the drug to be ineffective.

Magnesium Hydroxide side effects

Percentages show how often each reaction appears relative to total reports for magnesium hydroxide.

1
Chronic Kidney Disease18.5%1,915
2
Acute Kidney Injury11.0%1,136
3
Constipation8.6%892
4
Renal Failure8.4%872
5
Pain8.4%871
6
Fall7.3%752
7
Drug Ineffective6.4%664
8
Hypotension6.3%649
9
Cognitive Disorder6.2%643
10
Balance Disorder6.0%622
11
Orthostatic Hypotension6.0%616
12
Sedation5.5%573
13
Mobility Decreased5.4%554
14
Off Label Use5.3%551
15
End Stage Renal Disease5.2%540

These are voluntary reports and do not establish that magnesium hydroxide caused these reactions.

Report severity

74.2%Serious7,674 reports
36.3%Hospitalizations3,752 reports
10.9%Fatal1,127 reports

Seriousness is determined by the reporter, not by OpenClaim.

Magnesium Hydroxide drug interactions

Other drugs that appear in adverse event reports alongside magnesium hydroxide. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Omeprazole29.0%2,994
2
Esomeprazole19.4%2,004
3
Pantoprazole-sodium18.0%1,861
4
Lansoprazole18.0%1,856
5
Calcium-carbonate16.3%1,682
6
Famotidine14.1%1,455
7
Sodium-bicarbonate11.9%1,226
8
Dexlansoprazole7.9%816
9
Nitroglycerin7.2%740
10
Furosemide7.0%728
11
Cyclobenzaprine-hydrochloride6.7%693
12
Amlodipine6.6%680
13
Diltiazem6.3%652
14
Aspirin6.3%647
15
Morphine-sulfate6.2%645

Taken alongside

1
Acetaminophen32.3%3,344
2
Omeprazole21.4%2,210
3
Famotidine20.5%2,118
4
Aspirin20.0%2,063
5
Calcium-carbonate16.2%1,671
6
Ranitidine15.3%1,577
7
Sodium-bicarbonate15.0%1,553
8
Furosemide13.2%1,367
9
Ergocalciferol13.1%1,351
10
Ondansetron11.0%1,138
11
Albuterol10.6%1,095
12
Lisinopril10.5%1,089
13
Atorvastatin-calcium10.4%1,078
14
Levothyroxine-sodium10.4%1,076
15
Ibuprofen10.2%1,059

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports magnesium hydroxide side effects

55.3% of magnesium hydroxide adverse event reports involve female patients and 31.0% involve male patients. The largest age group is adult at 49%. These figures reflect who reports side effects, not underlying risk.

Sex

Female55.3%
Male31.0%
Unknown13.6%

Age group

< 20.8%
2–111.8%
12–170.8%
18–6449.1%
65+47.5%

What is magnesium hydroxide used for

Conditions and purposes for which patients were taking magnesium hydroxide when the adverse event was reported.

Abdominal DiscomfortAbdominal DistensionAbdominal HerniaAbdominal OperationAbdominal PainAbdominal Pain UpperAbdominal RigidityAccidental ExposureAccidental Exposure To ProductAccidental Exposure To Product By ChildAcid Reflux (esophageal)AcidosisAcute Myeloid LeukaemiaAdverse EventAlcohol Intolerance

Showing 15 of 286 indications

Magnesium Hydroxide brand names and reporting trend

Magnesium Hydroxide is sold under the brand name Famotidine, Calcium Carbonate, And Magnesium Hydroxide.

Brand names

Famotidine, Calcium Carbonate, And Magnesium Hydroxide7,183

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking magnesium hydroxide with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.