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Magnesium Acetate Tetrahydrate Side Effects

The most commonly reported side effects of magnesium acetate tetrahydrate include fatigue, nausea, and diarrhoea, based on 79,594 FDA adverse event reports from 2004 to 2025. 6.7% of reports found the drug to be ineffective.

Magnesium Acetate Tetrahydrate side effects

Percentages show how often each reaction appears relative to total reports for magnesium acetate tetrahydrate.

1
Fatigue10.4%8,300
2
Nausea8.1%6,410
3
Diarrhoea8.0%6,340
4
Headache7.1%5,671
5
Drug Ineffective6.7%5,363
6
Pain6.3%5,043
7
Off Label Use6.2%4,932
8
Dizziness5.8%4,652
9
Dyspnoea5.7%4,544
10
Arthralgia5.5%4,398
11
Asthenia5.1%4,023
12
Vomiting4.4%3,529
13
Malaise4.0%3,202
14
Pain In Extremity4.0%3,155
15
Rash3.8%3,060

These are voluntary reports and do not establish that magnesium acetate tetrahydrate caused these reactions.

Report severity

63.1%Serious50,212 reports
30.8%Hospitalizations24,537 reports
7.3%Fatal5,819 reports

Seriousness is determined by the reporter, not by OpenClaim.

Magnesium Acetate Tetrahydrate drug interactions

Other drugs that appear in adverse event reports alongside magnesium acetate tetrahydrate. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Lenalidomide6.8%5,374
2
Adalimumab5.0%3,995
3
Etanercept2.9%2,337
4
Rituximab2.8%2,265
5
Prednisone2.7%2,151
6
Methotrexate2.6%2,048
7
Acetaminophen2.4%1,939
8
Infliximab2.4%1,918
9
Tofacitinib2.4%1,908
10
Treprostinil2.3%1,813
11
Dupilumab2.2%1,772
12
Abatacept2.1%1,649
13
Certolizumab-pegol2.1%1,636
14
Tocilizumab2.1%1,635
15
Pomalidomide2.0%1,628

Taken alongside

1
Ergocalciferol39.5%31,456
2
Calcium23.6%18,793
3
Aspirin21.9%17,403
4
Acetaminophen20.8%16,536
5
Levothyroxine-sodium17.5%13,939
6
Cyanocobalamin14.4%11,480
7
Ascorbic-acid14.3%11,369
8
Omeprazole13.8%11,005
9
Pantoprazole-sodium12.3%9,766
10
Furosemide11.9%9,482
11
Atorvastatin-calcium11.9%9,474
12
Metoprolol11.5%9,187
13
Gabapentin11.5%9,116
14
Fish11.1%8,825
15
Albuterol11.0%8,776

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports magnesium acetate tetrahydrate side effects

65.5% of magnesium acetate tetrahydrate adverse event reports involve female patients and 27.7% involve male patients. The largest age group is adult at 50%. These figures reflect who reports side effects, not underlying risk.

Sex

Female65.5%
Male27.7%
Unknown6.9%

Age group

< 20.7%
2–111.0%
12–171.2%
18–6450.3%
65+46.8%

What is magnesium acetate tetrahydrate used for

Conditions and purposes for which patients were taking magnesium acetate tetrahydrate when the adverse event was reported.

Abdominal DiscomfortAbdominal DistensionAbdominal PainAbdominal Pain LowerAbdominal Pain UpperAbnormal FaecesAbnormal LabourAbortion ThreatenedAccessory Nerve DisorderAcid Base BalanceAcid Base Balance AbnormalAcidosisAcute Myocardial InfarctionAcute Respiratory FailureAdjuvant Therapy

Showing 15 of 868 indications

Magnesium Acetate Tetrahydrate brand names and reporting trend

Magnesium Acetate Tetrahydrate is sold under the brand name Plasma-lyte 56 And Dextrose 5% In Plastic Container.

Brand names

Plasma-lyte 56 And Dextrose 5% In Plastic Container82,190

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking magnesium acetate tetrahydrate with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.