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Mafenide Side Effects

The most commonly reported side effects of mafenide include pyrexia, sepsis, and hypotension, based on 41 FDA adverse event reports from 2004 to 2025. 9.8% of reports found the drug to be ineffective.

Mafenide side effects

Percentages show how often each reaction appears relative to total reports for mafenide.

1
Pyrexia9.8%4
2
Drug Ineffective9.8%4
3
Sepsis7.3%3
4
Hypotension7.3%3
5
Multiple Organ Dysfunction Syndrome7.3%3
6
Medication Error4.9%2
7
Acute Kidney Injury4.9%2
8
Dry Skin4.9%2
9
Peripheral Swelling4.9%2
10
Skin Fissures4.9%2
11
Wound Infection4.9%2
12
Erythema4.9%2
13
Fatigue4.9%2
14
Colon Cancer4.9%2
15
Nausea4.9%2

These are voluntary reports and do not establish that mafenide caused these reactions.

Report severity

80.5%Serious33 reports
34.1%Hospitalizations14 reports
9.8%Fatal4 reports

Seriousness is determined by the reporter, not by OpenClaim.

Mafenide drug interactions

Other drugs that appear in adverse event reports alongside mafenide. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Amikacin-sulfate14.6%6
2
Silver-sulfadiazine12.2%5
3
Amphotericin-b9.8%4
4
Fluconazole7.3%3
5
Voriconazole7.3%3
6
Lenalidomide4.9%2
7
Adalimumab4.9%2
8
Imipenem4.9%2
9
Azithromycin4.9%2
10
Tobramycin4.9%2
11
Tigecycline4.9%2
12
Piperacillin4.9%2
13
Tazobactam-sodium4.9%2
14
Ocrelizumab4.9%2
15
Vancomycin4.9%2

Taken alongside

1
Ascorbic-acid26.8%11
2
Ergocalciferol24.4%10
3
Acetaminophen24.4%10
4
Diphenhydramine17.1%7
5
Gabapentin17.1%7
6
Sulfamethoxazole17.1%7
7
Insulin14.6%6
8
Oxycodone14.6%6
9
Ferrous-sulfate14.6%6
10
Albuterol12.2%5
11
Carvedilol12.2%5
12
Epinephrine12.2%5
13
Calcium12.2%5
14
Ondansetron12.2%5
15
Furosemide12.2%5

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports mafenide side effects

51.2% of mafenide adverse event reports involve female patients and 34.1% involve male patients. The largest age group is adult at 63%. These figures reflect who reports side effects, not underlying risk.

Sex

Female51.2%
Male34.1%
Unknown14.6%

Age group

< 23.7%
2–113.7%
12–170.0%
18–6463.0%
65+29.6%

What is mafenide used for

Conditions and purposes for which patients were taking mafenide when the adverse event was reported.

CellulitisChronic Lymphocytic LeukaemiaDiverticulum IntestinalEnterobacter InfectionInfection ProphylaxisProduct Used For Unknown IndicationPyoderma GangrenosumProduct Used For Unknown IndicationStenotrophomonas InfectionStaphylococcal Skin InfectionThermal BurnThermal BurnWound InfectionWound Infection BacterialWound

Mafenide brand names and reporting trend

Mafenide is sold under the brand name Sulfamylon.

Brand names

Sulfamylon24

Quarterly reports (20042025)

200420152025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking mafenide with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.