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Macimorelin Side Effects

The most commonly reported side effects of macimorelin include off label use, treatment failure, and arthralgia, based on 435 FDA adverse event reports from 2017 to 2025.

Macimorelin side effects

Percentages show how often each reaction appears relative to total reports for macimorelin.

1
Off Label Use56.3%245
2
Treatment Failure6.7%29
3
Arthralgia5.5%24
4
Pain5.1%22
5
Graft Delamination4.6%20
6
Transplant Failure4.1%18
7
Procedural Pain2.8%12
8
Product Quality Issue1.6%7
9
Joint Lock1.6%7
10
Swelling1.4%6
11
Arthroscopy1.4%6
12
Fall1.4%6
13
Graft Complication1.1%5
14
Inadequate Osteointegration0.9%4
15
Graft Overgrowth0.9%4

These are voluntary reports and do not establish that macimorelin caused these reactions.

Report severity

21.6%Serious94 reports
1.8%Hospitalizations8 reports
0.7%Fatal3 reports

Seriousness is determined by the reporter, not by OpenClaim.

Macimorelin drug interactions

Other drugs that appear in adverse event reports alongside macimorelin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Aspirin0.2%1

Taken alongside

1
Ibuprofen0.9%4
2
Acetaminophen0.9%4
3
Gabapentin0.5%2
4
Hydrocodone0.5%2
5
Aspirin0.2%1
6
Celecoxib0.2%1
7
Hydrocortisone0.2%1
8
Metformin0.2%1
9
Insulin0.2%1
10
Olmesartan-medoxomil0.2%1
11
Pantoprazole-sodium0.2%1
12
Pregabalin0.2%1
13
Rosuvastatin0.2%1
14
Ergocalciferol0.2%1
15
Ondansetron0.2%1

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports macimorelin side effects

48.3% of macimorelin adverse event reports involve female patients and 40.2% involve male patients. The largest age group is adolescent at 64%. These figures reflect who reports side effects, not underlying risk.

Sex

Female48.3%
Male40.2%
Unknown11.5%

Age group

< 20.6%
2–110.3%
12–1763.8%
18–6435.0%
65+0.3%

What is macimorelin used for

Conditions and purposes for which patients were taking macimorelin when the adverse event was reported.

ArthralgiaBlood Growth Hormone AbnormalBone LesionCartilage InjuryChondropathyCraniocerebral InjuryCartilage InjuryChondropathyChondroplastyGrowth Hormone DeficiencyHypopituitarismJoint InjuryKnee DeformityKnee OperationOsteoarthritis

Showing 15 of 22 indications

Macimorelin brand names and reporting trend

Macimorelin is sold under the brand name Macrilen.

Brand names

Macrilen448

Quarterly reports (20172025)

20172020202220242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking macimorelin with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.