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Lutetium Side Effects

The most commonly reported side effects of lutetium include general physical health deterioration, ill-defined disorder, and death, based on 17,320 FDA adverse event reports from 2010 to 2025. 1.1% of reports found the drug to be ineffective.

#1 Reported: General Physical Health DeteriorationAll side effects ↓Top Co-Medication: Octreotide-acetateDrug interactions ↓63% of Reports Are ElderlyDemographics ↓

Lutetium side effects

Percentages show how often each reaction appears relative to total reports for lutetium.

1
General Physical Health Deterioration34.9%6,043
2
Ill-defined Disorder29.7%5,150
3
Death9.7%1,673
4
Malignant Neoplasm Progression3.8%663
5
Disease Progression2.7%475
6
Fatigue2.6%446
7
Laboratory Test Abnormal2.4%413
8
Platelet Count Decreased2.3%404
9
Nausea2.3%403
10
Covid-191.9%337
11
Diarrhoea1.8%310
12
Illness1.8%304
13
Anaemia1.6%284
14
Thrombocytopenia1.5%262
15
Malaise1.5%261

These are voluntary reports and do not establish that lutetium caused these reactions.

Report severity

31.2%Serious5,396 reports
7.8%Hospitalizations1,351 reports
12.9%Fatal2,239 reports

Seriousness is determined by the reporter, not by OpenClaim.

Lutetium drug interactions

Other drugs that appear in adverse event reports alongside lutetium. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Octreotide-acetate1.9%335
2
Everolimus0.7%123
3
Docetaxel0.6%108
4
Gallium0.6%106
5
Enzalutamide0.4%75
6
Lanreotide-acetate0.4%73
7
Abiraterone-acetate0.4%70
8
Amlodipine0.3%59
9
Leuprolide0.3%53
10
Ondansetron0.3%50
11
Metformin0.3%48
12
Apalutamide0.3%46
13
Loperamide-hydrochloride0.3%45
14
Cabazitaxel0.3%44
15
Capecitabine0.2%40

Taken alongside

1
Acetaminophen0.9%155
2
Ondansetron0.7%122
3
Leuprolide0.6%112
4
Amlodipine0.6%102
5
Lanreotide-acetate0.5%92
6
Omeprazole0.5%91
7
Prednisone0.5%89
8
Octreotide-acetate0.5%89
9
Hydrochlorothiazide0.5%86
10
Aspirin0.5%84
11
Oxycodone0.5%80
12
Ergocalciferol0.5%78
13
Dexamethasone0.4%75
14
Denosumab0.4%74
15
Metformin0.4%72

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports lutetium side effects

5.3% of lutetium adverse event reports involve female patients and 18.4% involve male patients. The largest age group is elderly at 63%. These figures reflect who reports side effects, not underlying risk.

Sex

Female5.3%
Male18.4%
Unknown76.3%

Age group

< 2<0.1%
2–110.3%
12–170.2%
18–6436.0%
65+63.5%

What is lutetium used for

Conditions and purposes for which patients were taking lutetium when the adverse event was reported.

Acth-producing Pituitary TumourAesthesioneuroblastomaAcute LeukaemiaAdenocarcinomaAdrenal Gland CancerAdverse Drug ReactionAesthesioneuroblastomaAnaplastic MeningiomaAscitesBrca2 Gene MutationBenign Lymph Node NeoplasmBone CancerBone Cancer MetastaticBone NeoplasmBone Pain

Showing 15 of 180 indications

Lutetium brand names and reporting trend

Lutetium is sold under brand names including Pluvicto, Lutathera.

Brand names

Pluvicto721
Lutathera12

Quarterly reports (2010–2025)

20102016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking lutetium with another medication?

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