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Lusutrombopag Side Effects

The most commonly reported side effects of lusutrombopag include nausea, death, and portal vein thrombosis, based on 39 FDA adverse event reports from 2018 to 2025. 7.7% of reports found the drug to be ineffective.

Lusutrombopag side effects

Percentages show how often each reaction appears relative to total reports for lusutrombopag.

1
Nausea7.7%3
2
Drug Ineffective7.7%3
3
Death7.7%3
4
Portal Vein Thrombosis5.1%2
5
Ascites5.1%2
6
Pancytopenia5.1%2
7
Mesenteric Vein Thrombosis5.1%2
8
Diarrhoea5.1%2
9
Pain5.1%2
10
Headache5.1%2
11
Hospitalisation5.1%2
12
Pulmonary Embolism5.1%2
13
Shock Haemorrhagic5.1%2
14
Hepatic Encephalopathy2.6%1
15
Hyperammonaemia2.6%1

These are voluntary reports and do not establish that lusutrombopag caused these reactions.

Report severity

69.2%Serious27 reports
17.9%Hospitalizations7 reports
20.5%Fatal8 reports

Seriousness is determined by the reporter, not by OpenClaim.

Lusutrombopag drug interactions

Other drugs that appear in adverse event reports alongside lusutrombopag. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Pegfilgrastim5.1%2
2
Epirubicin-hydrochloride2.6%1
3
Tolvaptan2.6%1
4
Avatrombopag-maleate2.6%1
5
Macitentan2.6%1
6
Capecitabine2.6%1
7
Trastuzumab2.6%1

Taken alongside

1
Spironolactone10.3%4
2
Furosemide10.3%4
3
Tipiracil7.7%3
4
Trifluridine7.7%3
5
Prednisone5.1%2
6
Propranolol-hydrochloride5.1%2
7
Pegfilgrastim5.1%2
8
Capecitabine5.1%2
9
Sucralfate2.6%1
10
Sitagliptin2.6%1
11
Tolvaptan2.6%1
12
Zinc-sulfate-heptahydrate-cupric-sulfate-manganese-sulfate-selenious-acid2.6%1
13
Insulin2.6%1
14
Deoxycholic-acid2.6%1
15
Buspirone-hydrochloride2.6%1

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports lusutrombopag side effects

48.7% of lusutrombopag adverse event reports involve female patients and 43.6% involve male patients. The largest age group is adult at 61%. These figures reflect who reports side effects, not underlying risk.

Sex

Female48.7%
Male43.6%
Unknown7.7%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6460.7%
65+39.3%

What is lusutrombopag used for

Conditions and purposes for which patients were taking lusutrombopag when the adverse event was reported.

Hepatic CancerLarge Intestine PolypPlatelet Count DecreasedProduct Used For Unknown IndicationProphylaxisProduct Used For Unknown IndicationRenal CancerThrombocytopeniaThrombocytopeniaVarices Oesophageal

Lusutrombopag brand names and reporting trend

Lusutrombopag is sold under the brand name Mulpleta.

Brand names

Mulpleta5

Quarterly reports (20182025)

2018202020222025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking lusutrombopag with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.