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Lurbinectedin Side Effects

The most commonly reported side effects of lurbinectedin include death, disease progression, and off label use, based on 1,021 FDA adverse event reports from 2013 to 2025.

Lurbinectedin side effects

Percentages show how often each reaction appears relative to total reports for lurbinectedin.

1
Death12.9%132
2
Disease Progression10.0%102
3
Off Label Use7.1%72
4
Neutropenia6.1%62
5
Nausea6.0%61
6
Thrombocytopenia5.1%52
7
Fatigue4.4%45
8
Febrile Neutropenia4.3%44
9
Asthenia4.1%42
10
Vomiting3.7%38
11
Anaemia3.5%36
12
Injection Site Reaction3.3%34
13
Acute Kidney Injury2.8%29
14
Diarrhoea2.6%27
15
Pneumonia2.6%27

These are voluntary reports and do not establish that lurbinectedin caused these reactions.

Report severity

80.9%Serious826 reports
35.2%Hospitalizations359 reports
25.7%Fatal262 reports

Seriousness is determined by the reporter, not by OpenClaim.

Lurbinectedin drug interactions

Other drugs that appear in adverse event reports alongside lurbinectedin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Atezolizumab7.2%74
2
Carboplatin6.5%66
3
Etoposide6.3%64
4
Irinotecan-hydrochloride4.0%41
5
Sodium-chloride2.7%28
6
Doxorubicin-hydrochloride1.3%13
7
Nivolumab1.0%10
8
Ipilimumab1.0%10
9
Pregabalin0.9%9
10
Trilaciclib-dihydrochloride0.9%9
11
Durvalumab0.9%9
12
Furosemide0.8%8
13
Pegfilgrastim0.8%8
14
Cisplatin0.6%6
15
Candesartan-cilexetil0.6%6

Taken alongside

1
Dexamethasone11.1%113
2
Ondansetron9.8%100
3
Levothyroxine-sodium7.5%77
4
Pantoprazole-sodium7.1%72
5
Acetaminophen6.8%69
6
Omeprazole5.0%51
7
Oxycodone4.2%43
8
Metformin3.7%38
9
Aspirin3.5%36
10
Metoprolol3.4%35
11
Atorvastatin-calcium3.2%33
12
Metoclopramide-hydrochloride3.0%31
13
Citalopram-hydrobromide2.9%30
14
Albuterol2.7%28
15
Lorazepam2.6%27

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports lurbinectedin side effects

29.8% of lurbinectedin adverse event reports involve female patients and 40.8% involve male patients. The largest age group is elderly at 55%. These figures reflect who reports side effects, not underlying risk.

Sex

Female29.8%
Male40.8%
Unknown29.4%

Age group

< 20.0%
2–110.0%
12–170.2%
18–6444.7%
65+55.1%

What is lurbinectedin used for

Conditions and purposes for which patients were taking lurbinectedin when the adverse event was reported.

Anaplastic Thyroid CancerAcute Myeloid LeukaemiaBladder CancerBrca1 Gene MutationBronchial CarcinomaBladder CancerBone SarcomaBreast CancerBronchial CarcinomaBronchial NeoplasmCervix Carcinoma Stage IiiChoroidal NeovascularisationColon CancerColorectal AdenocarcinomaEndometrial Adenocarcinoma

Showing 15 of 77 indications

Lurbinectedin brand names and reporting trend

Lurbinectedin is sold under the brand name Zepzelca.

Brand names

Zepzelca573

Quarterly reports (20132025)

201620242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking lurbinectedin with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.