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Lumefantrine Side Effects

The most commonly reported side effects of lumefantrine include pyrexia, vomiting, and maternal exposure during pregnancy, based on 270 FDA adverse event reports from 2006 to 2025. 3.7% of reports found the drug to be ineffective.

Lumefantrine side effects

Percentages show how often each reaction appears relative to total reports for lumefantrine.

1
Pyrexia7.4%20
2
Vomiting7.0%19
3
Maternal Exposure During Pregnancy5.6%15
4
Asthenia4.8%13
5
Headache4.4%12
6
Anaemia4.1%11
7
Malaise4.1%11
8
Product Use In Unapproved Indication4.1%11
9
Haemolytic Anaemia3.7%10
10
Drug Ineffective3.7%10
11
Foetal Exposure During Pregnancy3.7%10
12
Malaria3.7%10
13
Pyrexia3.3%9
14
Dyspnoea3.3%9
15
Dyspnoea3.3%9

These are voluntary reports and do not establish that lumefantrine caused these reactions.

Report severity

92.2%Serious249 reports
31.1%Hospitalizations84 reports
9.6%Fatal26 reports

Seriousness is determined by the reporter, not by OpenClaim.

Lumefantrine drug interactions

Other drugs that appear in adverse event reports alongside lumefantrine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Artemether61.5%166
2
Amoxicillin3.7%10
3
Ceftriaxone-sodium3.7%10
4
Acetaminophen3.3%9
5
Azithromycin3.3%9
6
Efavirenz2.2%6
7
Naproxen2.2%6
8
Atovaquone1.9%5
9
Dexamethasone1.9%5
10
Ritonavir1.9%5
11
Lopinavir1.9%5
12
Quinine-sulfate1.9%5
13
Doxycycline1.9%5
14
Artesunate1.9%5
15
Hydroxychloroquine-sulfate1.9%5

Taken alongside

1
Artemether14.4%39
2
Acetaminophen13.3%36
3
Quinine-sulfate4.8%13
4
Metronidazole4.8%13
5
Meropenem3.3%9
6
Ergocalciferol3.3%9
7
Artesunate3.3%9
8
Ceftriaxone-sodium3.3%9
9
Amoxicillin3.0%8
10
Lamivudine3.0%8
11
Hydroxychloroquine-sulfate2.6%7
12
Atovaquone2.2%6
13
Ascorbic-acid2.2%6
14
Nystatin2.2%6
15
Tramadol-hydrochloride2.2%6

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports lumefantrine side effects

48.5% of lumefantrine adverse event reports involve female patients and 37.8% involve male patients. The largest age group is adult at 64%. These figures reflect who reports side effects, not underlying risk.

Sex

Female48.5%
Male37.8%
Unknown13.7%

Age group

< 28.3%
2–1114.4%
12–178.9%
18–6463.9%
65+4.4%

What is lumefantrine used for

Conditions and purposes for which patients were taking lumefantrine when the adverse event was reported.

Antiretroviral TherapyBabesiosisBabesiosisCerebral MalariaChillsCovid-19Evidence Based TreatmentFoetal Exposure During PregnancyHiv InfectionHypersensitivityHyperthermiaInfectionInvestigationLyme DiseaseLyme Disease

Showing 15 of 27 indications

Lumefantrine brand names and reporting trend

Lumefantrine is sold under the brand name Coartem.

Brand names

Coartem83

Quarterly reports (20062025)

2010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking lumefantrine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.