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Loxapine Side Effects

The most commonly reported side effects of loxapine include coma, somnolence, and toxicity to various agents, based on 5,080 FDA adverse event reports from 2004 to 2025. 7.3% of reports found the drug to be ineffective.

Loxapine side effects

Percentages show how often each reaction appears relative to total reports for loxapine.

1
Drug Ineffective7.3%370
2
Coma6.8%346
3
Somnolence6.4%326
4
Toxicity To Various Agents5.4%273
5
Drug Interaction5.1%261
6
Poisoning Deliberate4.7%238
7
Weight Increased4.5%231
8
Off Label Use4.4%221
9
Suicide Attempt4.2%211
10
Akathisia4.0%201
11
Death3.8%191
12
Product Use In Unapproved Indication3.7%188
13
Drug Abuse3.7%187
14
Obsessive-compulsive Disorder3.3%169
15
Increased Appetite3.2%162

These are voluntary reports and do not establish that loxapine caused these reactions.

Report severity

94.7%Serious4,812 reports
53.3%Hospitalizations2,710 reports
16.7%Fatal849 reports

Seriousness is determined by the reporter, not by OpenClaim.

Loxapine drug interactions

Other drugs that appear in adverse event reports alongside loxapine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Olanzapine20.1%1,020
2
Diazepam19.1%970
3
Risperidone18.9%958
4
Quetiapine-fumarate18.4%935
5
Clozapine17.6%896
6
Aripiprazole14.1%718
7
Haloperidol11.0%558
8
Venlafaxine7.0%357
9
Oxazepam6.1%310
10
Eszopiclone5.9%301
11
Fluoxetine-hydrochloride5.6%286
12
Lithium5.6%283
13
Lamotrigine5.2%264
14
Gabapentin5.2%263
15
Citalopram-hydrobromide5.1%260

Taken alongside

1
Acetaminophen6.5%332
2
Diazepam5.6%286
3
Lorazepam5.4%272
4
Levothyroxine-sodium4.4%222
5
Quetiapine-fumarate4.2%213
6
Risperidone4.2%212
7
Metformin3.8%192
8
Olanzapine3.7%187
9
Valproate-sodium3.7%186
10
Clonazepam3.6%181
11
Pantoprazole-sodium3.5%176
12
Atorvastatin-calcium3.4%175
13
Eszopiclone3.4%172
14
Aripiprazole3.2%164
15
Benztropine-mesylate3.0%152

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports loxapine side effects

39.6% of loxapine adverse event reports involve female patients and 50.9% involve male patients. The largest age group is adult at 82%. These figures reflect who reports side effects, not underlying risk.

Sex

Female39.6%
Male50.9%
Unknown9.5%

Age group

< 20.4%
2–110.8%
12–172.7%
18–6481.7%
65+14.3%

What is loxapine used for

Conditions and purposes for which patients were taking loxapine when the adverse event was reported.

Abnormal BehaviourAbnormal DreamsAcute PsychosisAdenocarcinoma Of ColonAdjuvant TherapyAffective DisorderAggressionAgitationAntidepressant TherapyAntipsychotic Drug LevelAnxietyAnxiety DisorderAnxiolytic TherapyArthritisAsperger's Disorder

Showing 15 of 185 indications

Loxapine brand names and reporting trend

Loxapine is sold under brand names including Adasuve, Loxapine Succinate, Loxitane C.

Brand names

Adasuve4,998
Loxapine Succinate1,406
Loxitane C8

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking loxapine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.