OpenClaim

Lorcaserin Side Effects

The most commonly reported side effects of lorcaserin include acute kidney injury, syncope, and dizziness, based on 177 FDA adverse event reports from 2013 to 2025.

#1 Reported: Acute Kidney InjuryAll side effects ↓Top Co-Medication: FurosemideDrug interactions ↓58% of Reports Are ElderlyDemographics ↓

Lorcaserin side effects

Percentages show how often each reaction appears relative to total reports for lorcaserin.

1
Acute Kidney Injury8.5%15
2
Syncope7.9%14
3
Dizziness6.2%11
4
Atrial Fibrillation6.2%11
5
Mitral Valve Incompetence5.1%9
6
Pneumonia4.5%8
7
Cardiac Failure Congestive4.5%8
8
Suicidal Ideation4.5%8
9
Gastrointestinal Haemorrhage4.0%7
10
Transient Ischaemic Attack4.0%7
11
Angina Unstable4.0%7
12
Non-cardiac Chest Pain3.4%6
13
Aortic Valve Incompetence3.4%6
14
Chest Discomfort2.8%5
15
Dyspnoea2.8%5

These are voluntary reports and do not establish that lorcaserin caused these reactions.

Report severity

89.8%Serious159 reports
71.2%Hospitalizations126 reports
6.8%Fatal12 reports

Seriousness is determined by the reporter, not by OpenClaim.

Lorcaserin drug interactions

Other drugs that appear in adverse event reports alongside lorcaserin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Furosemide7.9%14
2
Metoprolol5.1%9
3
Aspirin3.4%6
4
Ibuprofen3.4%6
5
Spironolactone3.4%6
6
Pantoprazole-sodium2.8%5
7
Isosorbide2.8%5
8
Atorvastatin-calcium2.3%4
9
Vancomycin2.3%4
10
Nitroglycerin2.3%4
11
Terazosin-hydrochloride2.3%4
12
Omeprazole2.3%4
13
Bisoprolol-fumarate2.3%4
14
Amoxicillin2.3%4
15
Penicillin2.3%4

Taken alongside

1
Aspirin51.4%91
2
Metformin30.5%54
3
Atorvastatin-calcium27.1%48
4
Metoprolol21.5%38
5
Insulin20.9%37
6
Acetaminophen20.3%36
7
Carvedilol19.8%35
8
Furosemide19.2%34
9
Albuterol18.6%33
10
Nitroglycerin18.6%33
11
Hydrochlorothiazide18.1%32
12
Lisinopril18.1%32
13
Ergocalciferol18.1%32
14
Omeprazole17.5%31
15
Levothyroxine-sodium16.9%30

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports lorcaserin side effects

38.4% of lorcaserin adverse event reports involve female patients and 55.4% involve male patients. The largest age group is elderly at 58%. These figures reflect who reports side effects, not underlying risk.

Sex

Female38.4%
Male55.4%
Unknown6.2%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6442.3%
65+57.7%

What is lorcaserin used for

Conditions and purposes for which patients were taking lorcaserin when the adverse event was reported.

Drug AbuseDrug Use DisorderEx-tobacco UserLennox-gastaut SyndromeObesityProduct Used For Unknown IndicationProduct Used For Unknown IndicationSevere Myoclonic Epilepsy Of InfancyWeight ControlWeight DecreasedWeight Decreased

Lorcaserin brand names and reporting trend

Quarterly reports (2013–2025)

2013201620202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking lorcaserin with another medication?

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