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Lopinavir Side Effects

The most commonly reported side effects of lopinavir include drug interaction, off label use, and foetal exposure during pregnancy, based on 17,267 FDA adverse event reports from 2004 to 2025.

Lopinavir side effects

Percentages show how often each reaction appears relative to total reports for lopinavir.

1
Drug Interaction8.3%1,439
2
Off Label Use7.6%1,313
3
Foetal Exposure During Pregnancy6.6%1,134
4
Depression6.5%1,129
5
Drug Exposure During Pregnancy4.6%793
6
Anxiety4.0%686
7
Pain3.6%621
8
Emotional Distress3.3%573
9
Exposure During Pregnancy3.0%521
10
Anhedonia2.9%507
11
Diarrhoea2.9%493
12
Nausea2.8%490
13
Chronic Kidney Disease2.6%448
14
Vomiting2.6%447
15
Virologic Failure2.5%440

These are voluntary reports and do not establish that lopinavir caused these reactions.

Report severity

93.2%Serious16,096 reports
35.2%Hospitalizations6,072 reports
12.8%Fatal2,217 reports

Seriousness is determined by the reporter, not by OpenClaim.

Lopinavir drug interactions

Other drugs that appear in adverse event reports alongside lopinavir. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Ritonavir70.3%12,136
2
Lamivudine31.8%5,491
3
Tenofovir28.7%4,964
4
Zidovudine21.3%3,683
5
Emtricitabine18.0%3,114
6
Efavirenz13.0%2,249
7
Abacavir10.1%1,750
8
Raltegravir-potassium8.8%1,524
9
Atazanavir-sulfate7.6%1,309
10
Nevirapine7.2%1,236
11
Didanosine7.1%1,224
12
Stavudine6.9%1,192
13
Hydroxychloroquine-sulfate4.3%751
14
Quetiapine-fumarate4.3%740
15
Clonazepam3.9%682

Taken alongside

1
Ritonavir24.9%4,304
2
Lamivudine15.6%2,694
3
Tenofovir13.0%2,246
4
Emtricitabine9.9%1,708
5
Zidovudine7.7%1,336
6
Abacavir7.3%1,254
7
Sulfamethoxazole6.3%1,085
8
Trimethoprim5.8%1,009
9
Enfuvirtide4.8%836
10
Raltegravir-potassium4.1%706
11
Efavirenz3.5%611
12
Acetaminophen3.5%597
13
Azithromycin3.4%586
14
Didanosine3.1%541
15
Fluconazole2.9%509

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports lopinavir side effects

31.1% of lopinavir adverse event reports involve female patients and 53.2% involve male patients. The largest age group is adult at 80%. These figures reflect who reports side effects, not underlying risk.

Sex

Female31.1%
Male53.2%
Unknown15.6%

Age group

< 26.9%
2–111.7%
12–171.4%
18–6479.9%
65+10.2%

What is lopinavir used for

Conditions and purposes for which patients were taking lopinavir when the adverse event was reported.

Accidental ExposureAccidental Exposure To ProductAcquired Immunodeficiency SyndromeAcute Hiv InfectionAcute Respiratory Distress SyndromeAids Related ComplicationAnaemiaAntiretroviral TherapyAntiviral ProphylaxisAntiviral TreatmentAsymptomatic Hiv InfectionAsymptomatic Human Immunodeficiency Virus Type I InfectionAutoimmune DisorderAcquired Immunodeficiency SyndromeAcute Respiratory Distress Syndrome

Showing 15 of 178 indications

Lopinavir brand names and reporting trend

Lopinavir is sold under the brand name Lopinavir And Ritonavir.

Brand names

Lopinavir And Ritonavir2,344

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking lopinavir with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.