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Loncastuximab Side Effects

The most commonly reported side effects of loncastuximab include death, disease progression, and rash, based on 334 FDA adverse event reports from 2008 to 2025.

Loncastuximab side effects

Percentages show how often each reaction appears relative to total reports for loncastuximab.

1
Death12.3%41
2
Disease Progression8.1%27
3
Rash6.0%20
4
Pleural Effusion6.0%20
5
Photosensitivity Reaction4.8%16
6
Thrombocytopenia4.5%15
7
Fatigue4.2%14
8
Covid-193.9%13
9
Pneumonia3.9%13
10
Oedema3.9%13
11
Neutropenia3.6%12
12
Anaemia3.3%11
13
Sepsis2.7%9
14
Dyspnoea2.7%9
15
Platelet Count Decreased2.7%9

These are voluntary reports and do not establish that loncastuximab caused these reactions.

Report severity

74.3%Serious248 reports
31.7%Hospitalizations106 reports
29.9%Fatal100 reports

Seriousness is determined by the reporter, not by OpenClaim.

Loncastuximab drug interactions

Other drugs that appear in adverse event reports alongside loncastuximab. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Rituximab16.5%55
2
Polatuzumab-vedotin-piiq6.9%23
3
Prednisone6.6%22
4
Cyclophosphamide6.3%21
5
Doxorubicin-hydrochloride6.0%20
6
Vincristine-sulfate6.0%20
7
Lenalidomide4.2%14
8
Ibrutinib3.0%10
9
Dexamethasone3.0%10
10
Bendamustine-hydrochloride3.0%10
11
Tafasitamab-cxix2.1%7
12
Etoposide1.8%6
13
Oxaliplatin1.8%6
14
Gemcitabine1.8%6
15
Obinutuzumab1.8%6

Taken alongside

1
Dexamethasone11.7%39
2
Acyclovir6.3%21
3
Trimethoprim5.4%18
4
Sulfamethoxazole5.1%17
5
Ondansetron4.5%15
6
Prednisone3.9%13
7
Allopurinol3.9%13
8
Aspirin3.6%12
9
Omeprazole3.3%11
10
Vincristine-sulfate3.3%11
11
Metformin3.0%10
12
Gabapentin3.0%10
13
Cyclophosphamide3.0%10
14
Etoposide3.0%10
15
Acetaminophen2.7%9

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports loncastuximab side effects

29.3% of loncastuximab adverse event reports involve female patients and 47.6% involve male patients. The largest age group is adult at 52%. These figures reflect who reports side effects, not underlying risk.

Sex

Female29.3%
Male47.6%
Unknown23.1%

Age group

< 20.0%
2–110.0%
12–170.4%
18–6451.7%
65+47.9%

What is loncastuximab used for

Conditions and purposes for which patients were taking loncastuximab when the adverse event was reported.

Aspartate Aminotransferase IncreasedB-cell LymphomaBreast Cancer FemaleCentral Nervous System LymphomaChronic Lymphocytic LeukaemiaDiffuse Large B-cell LymphomaDiffuse Large B-cell LymphomaDiffuse Large B-cell Lymphoma RecurrentDiffuse Large B-cell Lymphoma RefractoryDiffuse Large B-cell Lymphoma Stage IvExtranodal Marginal Zone B-cell Lymphoma (malt Type)Follicular LymphomaFollicular Lymphoma RefractoryFollicular Lymphoma Stage IHaematological Malignancy

Showing 15 of 30 indications

Loncastuximab brand names and reporting trend

Loncastuximab is sold under the brand name Zynlonta.

Brand names

Zynlonta194

Quarterly reports (20082025)

20082025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking loncastuximab with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.