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Lonapegsomatropin Side Effects

The most commonly reported side effects of lonapegsomatropin include product dose omission issue, headache, and injection site pain, based on 549 FDA adverse event reports from 2021 to 2025.

Lonapegsomatropin side effects

Percentages show how often each reaction appears relative to total reports for lonapegsomatropin.

1
Product Dose Omission Issue19.5%107
2
Headache10.4%57
3
Injection Site Pain8.6%47
4
Device Use Error8.0%44
5
Device Malfunction5.6%31
6
Therapy Interrupted4.7%26
7
Treatment Noncompliance4.7%26
8
Incorrect Dose Administered4.2%23
9
Nausea4.0%22
10
Off Label Use4.0%22
11
Vomiting3.8%21
12
Wrong Technique In Device Usage Process3.3%18
13
Fatigue3.1%17
14
Liquid Product Physical Issue3.1%17
15
Rash2.7%15

These are voluntary reports and do not establish that lonapegsomatropin caused these reactions.

Report severity

8.6%Serious47 reports
2.7%Hospitalizations15 reports
0.0%Fatal0 reports

Seriousness is determined by the reporter, not by OpenClaim.

Lonapegsomatropin drug interactions

Other drugs that appear in adverse event reports alongside lonapegsomatropin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Dupilumab0.9%5
2
Vamorolone0.7%4
3
Somatropin0.5%3
4
Metformin0.4%2
5
Lisdexamfetamine-dimesylate0.4%2
6
Risankizumab-rzaa0.4%2
7
Leniolisib-phosphate0.4%2
8
Anastrozole0.2%1
9
Estropipate0.2%1
10
Risperidone0.2%1
11
Burosumab-twza0.2%1
12
Buspirone-hydrochloride0.2%1
13
Glycerol-phenylbutyrate0.2%1
14
Bupropion0.2%1
15
Amoxicillin0.2%1

Taken alongside

1
Levothyroxine-sodium8.2%45
2
Hydrocortisone5.8%32
3
Cetirizine-hydrochloride3.5%19
4
Somatropin3.5%19
5
Albuterol2.6%14
6
Ergocalciferol2.2%12
7
Anastrozole2.2%12
8
Desmopressin-acetate2.0%11
9
Ascorbic-acid1.8%10
10
Cyproheptadine-hydrochloride1.6%9
11
Escitalopram-oxalate1.6%9
12
Acetaminophen1.5%8
13
Ibuprofen1.3%7
14
Montelukast-sodium1.3%7
15
Methylphenidate1.3%7

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports lonapegsomatropin side effects

1.1% of lonapegsomatropin adverse event reports involve female patients and 6.7% involve male patients. The largest age group is adolescent at 53%. These figures reflect who reports side effects, not underlying risk.

Sex

Female1.1%
Male6.7%
Unknown92.2%

Age group

< 20.0%
2–1144.4%
12–1752.8%
18–642.8%
65+0.0%

What is lonapegsomatropin used for

Conditions and purposes for which patients were taking lonapegsomatropin when the adverse event was reported.

Blood Growth Hormone AbnormalBlood Growth Hormone DecreasedCongenital AnomalyConstipationDelayed PubertyDigeorge^s SyndromeDigestive Enzyme AbnormalDysmorphismEhlers-danlos SyndromeFailure To ThriveGait DisturbanceGrowth DisorderGrowth FailureGrowth Hormone DeficiencyGrowth Retardation

Showing 15 of 29 indications

Lonapegsomatropin brand names and reporting trend

Lonapegsomatropin is sold under the brand name Skytrofa.

Brand names

Skytrofa3

Quarterly reports (20212025)

202220242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking lonapegsomatropin with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.