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Lonafarnib Side Effects

The most commonly reported side effects of lonafarnib include product dose omission issue, diarrhoea, and vomiting, based on 93 FDA adverse event reports from 2004 to 2025.

Lonafarnib side effects

Percentages show how often each reaction appears relative to total reports for lonafarnib.

1
Product Dose Omission Issue24.7%23
2
Diarrhoea14.0%13
3
Vomiting10.8%10
4
Febrile Neutropenia4.3%4
5
Diarrhoea4.3%4
6
Nausea4.3%4
7
Vomiting4.3%4
8
Headache4.3%4
9
Asthenia3.2%3
10
Fatigue3.2%3
11
Product Supply Issue3.2%3
12
Malaise3.2%3
13
Abdominal Pain Upper3.2%3
14
Cardiac Operation3.2%3
15
Death3.2%3

These are voluntary reports and do not establish that lonafarnib caused these reactions.

Report severity

61.3%Serious57 reports
39.8%Hospitalizations37 reports
16.1%Fatal15 reports

Seriousness is determined by the reporter, not by OpenClaim.

Lonafarnib drug interactions

Other drugs that appear in adverse event reports alongside lonafarnib. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Docetaxel12.9%12
2
Pravastatin-sodium6.5%6
3
Anastrozole5.4%5
4
Temozolomide5.4%5
5
Paclitaxel3.2%3
6
Trastuzumab3.2%3
7
Everolimus3.2%3
8
Fluorouracil2.2%2
9
Doxorubicin-hydrochloride2.2%2
10
Cyclophosphamide2.2%2
11
Carbamazepine1.1%1
12
Dexamethasone1.1%1
13
Digoxin1.1%1
14
Zoledronic-acid1.1%1
15
Imatinib-mesylate1.1%1

Taken alongside

1
Aspirin12.9%12
2
Acetaminophen10.8%10
3
Levothyroxine-sodium8.6%8
4
Oxycodone8.6%8
5
Ergocalciferol7.5%7
6
Loperamide-hydrochloride6.5%6
7
Dexamethasone6.5%6
8
Atenolol5.4%5
9
Omeprazole4.3%4
10
Potassium-chloride3.2%3
11
Lorazepam3.2%3
12
Apomorphine-hydrochloride3.2%3
13
Promethazine-hydrochloride3.2%3
14
Ondansetron3.2%3
15
Levetiracetam3.2%3

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports lonafarnib side effects

45.2% of lonafarnib adverse event reports involve female patients and 37.6% involve male patients. The largest age group is adult at 40%. These figures reflect who reports side effects, not underlying risk.

Sex

Female45.2%
Male37.6%
Unknown17.2%

Age group

< 20.0%
2–1117.5%
12–1719.3%
18–6440.4%
65+22.8%

What is lonafarnib used for

Conditions and purposes for which patients were taking lonafarnib when the adverse event was reported.

AdenocarcinomaBrain Stem GliomaBreast CancerBreast Cancer MetastaticChemotherapyChronic Myeloid LeukaemiaDrug InteractionEndocrine DisorderGlioblastoma MultiformeGliomaGilbert^s SyndromeHepatic Cancer MetastaticHepatic Neoplasm MalignantHepatitis BHepatitis D

Showing 15 of 22 indications

Lonafarnib brand names and reporting trend

Lonafarnib is sold under the brand name Zokinvy.

Brand names

Zokinvy62

Quarterly reports (20042025)

200420202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking lonafarnib with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.