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Lomustine Side Effects

The most commonly reported side effects of lomustine include death, off label use, and nausea, based on 2,530 FDA adverse event reports from 2004 to 2025. 4.9% of reports found the drug to be ineffective.

Lomustine side effects

Percentages show how often each reaction appears relative to total reports for lomustine.

1
Death9.8%248
2
Off Label Use9.2%233
3
Nausea8.7%220
4
Fatigue7.9%200
5
Thrombocytopenia6.2%158
6
Disease Progression5.4%136
7
Drug Ineffective4.9%124
8
Neutropenia4.7%119
9
Platelet Count Decreased4.4%112
10
Vomiting4.0%102
11
Seizure3.3%84
12
Headache3.2%82
13
Product Use In Unapproved Indication3.0%76
14
Constipation2.7%69
15
Malignant Neoplasm Progression2.5%64

These are voluntary reports and do not establish that lomustine caused these reactions.

Report severity

68.4%Serious1,730 reports
20.9%Hospitalizations529 reports
22.6%Fatal572 reports

Seriousness is determined by the reporter, not by OpenClaim.

Lomustine drug interactions

Other drugs that appear in adverse event reports alongside lomustine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Procarbazine-hydrochloride32.8%831
2
Vincristine-sulfate19.4%491
3
Bevacizumab15.3%387
4
Temozolomide12.5%315
5
Etoposide9.2%234
6
Cisplatin8.2%208
7
Cyclophosphamide7.5%191
8
Carboplatin5.8%148
9
Cytarabine5.2%131
10
Vinblastine-sulfate4.5%114
11
Melphalan4.2%107
12
Dexamethasone4.0%102
13
Prednisone3.2%82
14
Doxorubicin-hydrochloride3.0%77
15
Methotrexate2.8%72

Taken alongside

1
Levetiracetam17.0%430
2
Ondansetron12.1%306
3
Dexamethasone11.9%302
4
Vincristine-sulfate6.8%173
5
Acetaminophen5.7%144
6
Temozolomide4.4%112
7
Procarbazine-hydrochloride3.9%98
8
Sulfamethoxazole3.7%94
9
Trimethoprim3.5%88
10
Omeprazole3.2%81
11
Lorazepam3.0%77
12
Pantoprazole-sodium2.7%69
13
Lacosamide2.6%67
14
Ergocalciferol2.6%66
15
Bevacizumab2.5%63

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports lomustine side effects

36.4% of lomustine adverse event reports involve female patients and 47.5% involve male patients. The largest age group is adult at 67%. These figures reflect who reports side effects, not underlying risk.

Sex

Female36.4%
Male47.5%
Unknown16.1%

Age group

< 20.8%
2–118.3%
12–177.7%
18–6466.7%
65+16.4%

What is lomustine used for

Conditions and purposes for which patients were taking lomustine when the adverse event was reported.

Acute Biphenotypic LeukaemiaAcute Lymphocytic LeukaemiaAcute Myeloid LeukaemiaAcute Promyelocytic LeukaemiaAdenocarcinoma Of ColonAdenomatous Polyposis ColiAnaplastic AstrocytomaAnaplastic Large Cell Lymphoma T- And Null-cell TypesAnaplastic Large-cell LymphomaAnaplastic OligodendrogliomaAstrocytomaAstrocytoma MalignantAstrocytoma, Low GradeAutologous Haematopoietic Stem Cell TransplantAcute Leukaemia

Showing 15 of 159 indications

Lomustine brand names and reporting trend

Lomustine is sold under the brand name Gleostine.

Brand names

Gleostine1,897

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking lomustine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.