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Lomitapide Side Effects

The most commonly reported side effects of lomitapide include diarrhoea, weight decreased, and therapy cessation, based on 4,001 FDA adverse event reports from 2013 to 2025.

Lomitapide side effects

Percentages show how often each reaction appears relative to total reports for lomitapide.

1
Diarrhoea28.5%1,139
2
Weight Decreased21.6%866
3
Therapy Cessation20.1%806
4
Nausea15.1%605
5
Abdominal Pain Upper7.4%295
6
Flatulence6.3%251
7
Abdominal Discomfort6.1%243
8
Off Label Use5.8%232
9
Vomiting5.7%229
10
Fatigue5.3%214
11
Hepatic Enzyme Increased5.0%200
12
Inappropriate Schedule Of Drug Administration4.8%193
13
Drug Dose Omission4.7%187
14
Abdominal Pain4.5%181
15
Constipation4.3%172

These are voluntary reports and do not establish that lomitapide caused these reactions.

Report severity

35.0%Serious1,401 reports
11.0%Hospitalizations440 reports
2.8%Fatal111 reports

Seriousness is determined by the reporter, not by OpenClaim.

Lomitapide drug interactions

Other drugs that appear in adverse event reports alongside lomitapide. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Rosuvastatin4.4%175
2
Ezetimibe4.2%168
3
Atorvastatin-calcium3.8%154
4
Evolocumab3.7%147
5
Simvastatin2.8%112
6
Lovastatin2.7%109
7
Alirocumab1.6%65
8
Pravastatin-sodium1.4%57
9
Cholestyramine1.4%56
10
Probucol1.4%55
11
Fluvastatin-sodium1.4%55
12
Niacin1.3%54
13
Colesevelam-hydrochloride1.2%50
14
Icosapent-ethyl1.0%42
15
Warfarin0.8%32

Taken alongside

1
Aspirin25.2%1,010
2
Vitamin-e21.0%841
3
Ezetimibe20.3%812
4
Rosuvastatin16.7%669
5
Metoprolol11.3%451
6
Ergocalciferol11.2%450
7
Atorvastatin-calcium8.9%356
8
Clopidogrel-bisulfate8.8%351
9
Fish7.6%306
10
Nitroglycerin7.5%301
11
Omeprazole7.4%298
12
Amlodipine7.4%296
13
Levothyroxine-sodium7.4%295
14
Lisinopril6.6%263
15
Furosemide6.4%257

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports lomitapide side effects

49.5% of lomitapide adverse event reports involve female patients and 27.2% involve male patients. The largest age group is adult at 67%. These figures reflect who reports side effects, not underlying risk.

Sex

Female49.5%
Male27.2%
Unknown23.4%

Age group

< 2<0.1%
2–111.4%
12–170.8%
18–6466.8%
65+31.1%

What is lomitapide used for

Conditions and purposes for which patients were taking lomitapide when the adverse event was reported.

ArthritisArteriosclerosisBlood CholesterolBlood Cholesterol AbnormalBlood Cholesterol IncreasedBlood Triglycerides IncreasedCarotid Artery DiseaseConnective Tissue DisorderCoronary Artery DiseaseCarotid Artery StenosisDrug IntoleranceDyslipidaemiaFatigueFamilial HypertriglyceridaemiaHepatic Atrophy

Showing 15 of 47 indications

Lomitapide brand names and reporting trend

Lomitapide is sold under the brand name Juxtapid.

Brand names

Juxtapid644

Quarterly reports (20132025)

20132016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking lomitapide with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.