OpenClaim

Lixisenatide Side Effects

The most commonly reported side effects of lixisenatide include blood glucose increased, product storage error, and accidental exposure to product, based on 3,472 FDA adverse event reports from 2013 to 2025. 3.3% of reports found the drug to be ineffective.

Lixisenatide side effects

Percentages show how often each reaction appears relative to total reports for lixisenatide.

1
Blood Glucose Increased13.1%455
2
Product Storage Error11.2%388
3
Accidental Exposure To Product8.4%290
4
Off Label Use7.4%257
5
Exposure Via Skin Contact4.4%154
6
Nausea4.4%153
7
Visual Impairment4.0%140
8
Inappropriate Schedule Of Product Administration4.0%140
9
Drug Ineffective3.3%115
10
Blood Glucose Decreased2.7%94
11
Device Issue2.6%89
12
Diarrhoea2.3%80
13
Vomiting2.3%79
14
Wrong Technique In Device Usage Process2.2%75
15
Injection Site Pain2.1%74

These are voluntary reports and do not establish that lixisenatide caused these reactions.

Report severity

21.1%Serious732 reports
7.9%Hospitalizations275 reports
1.7%Fatal58 reports

Seriousness is determined by the reporter, not by OpenClaim.

Lixisenatide drug interactions

Other drugs that appear in adverse event reports alongside lixisenatide. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Insulin87.8%3,047
2
Metformin1.3%45
3
Empagliflozin1.0%35
4
Dulaglutide0.8%27
5
Dapagliflozin0.7%26
6
Semaglutide0.5%18
7
Pioglitazone-hydrochloride0.5%17
8
Lenalidomide0.5%16
9
Treprostinil0.4%14
10
Mifepristone0.3%11
11
Liraglutide0.3%10
12
Alirocumab0.3%10
13
Adalimumab0.3%9
14
Linezolid0.2%8
15
Apixaban0.2%8

Taken alongside

1
Insulin17.7%615
2
Metformin8.7%302
3
Atorvastatin-calcium4.1%144
4
Aspirin2.9%101
5
Amlodipine2.1%74
6
Acetaminophen2.0%71
7
Empagliflozin1.9%65
8
Lisinopril1.8%63
9
Ergocalciferol1.8%63
10
Metoprolol1.8%62
11
Levothyroxine-sodium1.6%57
12
Losartan-potassium1.6%57
13
Gabapentin1.6%55
14
Rosuvastatin1.4%50
15
Glimepiride1.4%48

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports lixisenatide side effects

47.5% of lixisenatide adverse event reports involve female patients and 37.1% involve male patients. The largest age group is adult at 52%. These figures reflect who reports side effects, not underlying risk.

Sex

Female47.5%
Male37.1%
Unknown15.5%

Age group

< 2<0.1%
2–110.0%
12–170.0%
18–6452.4%
65+47.6%

What is lixisenatide used for

Conditions and purposes for which patients were taking lixisenatide when the adverse event was reported.

Blood GlucoseBlood Glucose AbnormalBlood Glucose IncreasedBlood GlucoseBlood Glucose AbnormalBlood Glucose IncreasedDiabetes MellitusDiabetes Mellitus Inadequate ControlDiabetes Mellitus ManagementDermatitis AtopicDiabetes MellitusDiabetes Mellitus Inadequate ControlDiabetes Mellitus ManagementDiabetic NephropathyDiabetic Neuropathy

Showing 15 of 43 indications

Lixisenatide brand names and reporting trend

Lixisenatide is sold under the brand name Soliqua 100/33.

Brand names

Soliqua 100/33160

Quarterly reports (20132025)

20132016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking lixisenatide with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.