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Lisinopril Side Effects

The most commonly reported side effects of lisinopril include fatigue, diarrhoea, and nausea, based on 329,200 FDA adverse event reports from 2004 to 2025. 4.8% of reports found the drug to be ineffective.

Lisinopril side effects

Percentages show how often each reaction appears relative to total reports for lisinopril.

1
Fatigue5.5%17,976
2
Drug Ineffective4.8%15,858
3
Diarrhoea4.7%15,431
4
Nausea4.6%15,299
5
Pain3.5%11,506
6
Headache3.4%11,266
7
Dyspnoea3.4%11,208
8
Dizziness3.3%10,853
9
Off Label Use3.3%10,810
10
Acute Kidney Injury3.0%10,009
11
Chronic Kidney Disease2.9%9,397
12
Vomiting2.7%9,013
13
Asthenia2.7%8,862
14
Arthralgia2.6%8,476
15
Fall2.4%7,779

These are voluntary reports and do not establish that lisinopril caused these reactions.

Report severity

61.0%Serious200,976 reports
32.1%Hospitalizations105,559 reports
8.1%Fatal26,560 reports

Seriousness is determined by the reporter, not by OpenClaim.

Lisinopril drug interactions

Other drugs that appear in adverse event reports alongside lisinopril. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Adalimumab4.8%15,770
2
Lenalidomide4.1%13,523
3
Omeprazole3.3%10,787
4
Esomeprazole3.0%9,716
5
Pantoprazole-sodium2.4%7,929
6
Etanercept2.1%6,822
7
Lansoprazole2.0%6,595
8
Metformin2.0%6,472
9
Pregabalin1.7%5,682
10
Rosiglitazone-maleate1.7%5,546
11
Amlodipine1.6%5,259
12
Aspirin1.6%5,189
13
Hydrochlorothiazide1.6%5,150
14
Apremilast1.6%5,122
15
Rivaroxaban1.5%4,986

Taken alongside

1
Aspirin22.3%73,361
2
Atorvastatin-calcium15.9%52,358
3
Metformin15.8%51,971
4
Metoprolol14.6%48,018
5
Acetaminophen13.8%45,414
6
Ergocalciferol13.1%43,112
7
Amlodipine12.9%42,536
8
Furosemide12.6%41,448
9
Levothyroxine-sodium12.2%40,215
10
Omeprazole11.5%37,793
11
Hydrochlorothiazide11.2%37,000
12
Simvastatin11.0%36,096
13
Gabapentin9.6%31,624
14
Insulin9.1%29,984
15
Albuterol8.7%28,615

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports lisinopril side effects

49.1% of lisinopril adverse event reports involve female patients and 45.1% involve male patients. The largest age group is adult at 51%. These figures reflect who reports side effects, not underlying risk.

Sex

Female49.1%
Male45.1%
Unknown5.8%

Age group

< 20.1%
2–110.2%
12–170.5%
18–6450.9%
65+48.3%

What is lisinopril used for

Conditions and purposes for which patients were taking lisinopril when the adverse event was reported.

Abdominal DiscomfortAbdominal Pain UpperAccelerated HypertensionAccidental Drug Intake By ChildAccidental Exposure To ProductAccidental Exposure To Product By ChildAccidental OverdoseAcute Coronary SyndromeAcute Kidney InjuryAcute Lymphocytic LeukaemiaAcute Myeloid LeukaemiaAcute Myocardial InfarctionAcute Prerenal FailureAdenocarcinoma Of ColonAdjuvant Therapy

Showing 15 of 1,084 indications

Lisinopril brand names and reporting trend

Lisinopril is sold under the brand name Qbrelis.

Brand names

Qbrelis313,028

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking lisinopril with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.