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Lipase Side Effects

The most commonly reported side effects of lipase include diarrhoea, death, and nausea, based on 43,001 FDA adverse event reports from 2004 to 2025. 2.9% of reports found the drug to be ineffective.

Lipase side effects

Percentages show how often each reaction appears relative to total reports for lipase.

1
Diarrhoea8.8%3,767
2
Death4.9%2,125
3
Nausea4.6%1,973
4
Weight Decreased4.2%1,803
5
Fatigue4.1%1,761
6
Infective Pulmonary Exacerbation Of Cystic Fibrosis4.1%1,755
7
Abdominal Pain3.7%1,609
8
Vomiting3.5%1,492
9
Pain3.1%1,319
10
Abdominal Pain Upper3.0%1,291
11
Dyspnoea3.0%1,291
12
Hospitalisation2.9%1,266
13
Off Label Use2.9%1,260
14
Pneumonia2.9%1,257
15
Drug Ineffective2.9%1,246

These are voluntary reports and do not establish that lipase caused these reactions.

Report severity

71.7%Serious30,836 reports
39.4%Hospitalizations16,936 reports
9.8%Fatal4,198 reports

Seriousness is determined by the reporter, not by OpenClaim.

Lipase drug interactions

Other drugs that appear in adverse event reports alongside lipase. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Pancrelipase-amylase44.1%18,963
2
Protease44.1%18,963
3
Ivacaftor17.2%7,383
4
Lumacaftor5.9%2,518
5
Elexacaftor-ivacaftor-tezacaftor5.2%2,215
6
Aztreonam4.5%1,918
7
Tobramycin3.8%1,640
8
Dornase-alfa2.2%941
9
Gemcitabine2.1%897
10
Paclitaxel1.6%674
11
Omeprazole1.1%483
12
Oxaliplatin1.0%434
13
Adalimumab1.0%413
14
Fluorouracil0.9%373
15
Capecitabine0.9%371

Taken alongside

1
Pancrelipase-amylase50.3%21,613
2
Protease50.2%21,604
3
Albuterol21.6%9,290
4
Dornase-alfa17.6%7,573
5
Ergocalciferol14.8%6,364
6
Omeprazole13.3%5,700
7
Fluticasone11.9%5,101
8
Azithromycin11.1%4,786
9
Insulin11.0%4,714
10
Sodium-chloride9.8%4,228
11
Acetaminophen8.9%3,809
12
Tobramycin7.6%3,253
13
Pantoprazole-sodium7.2%3,114
14
Ondansetron6.7%2,891
15
Levothyroxine-sodium6.4%2,736

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports lipase side effects

51.4% of lipase adverse event reports involve female patients and 40.6% involve male patients. The largest age group is adult at 48%. These figures reflect who reports side effects, not underlying risk.

Sex

Female51.4%
Male40.6%
Unknown8.0%

Age group

< 20.8%
2–116.5%
12–176.9%
18–6447.9%
65+37.9%

What is lipase used for

Conditions and purposes for which patients were taking lipase when the adverse event was reported.

Abdominal DiscomfortAbdominal DistensionAbdominal PainAbdominal Pain UpperAbnormal FaecesAcneAdenocarcinomaAdenocarcinoma PancreasAdverse EventAlcoholic Liver DiseaseAlcoholic PancreatitisAmino Acid Catabolism DisorderAmino Acid Metabolism DisorderAmylaseAmylase Decreased

Showing 15 of 578 indications

Lipase brand names and reporting trend

Lipase is sold under the brand name Cotazym.

Brand names

Cotazym3,014

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking lipase with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.