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Liothyronine Side Effects

The most commonly reported side effects of liothyronine include fatigue, headache, and nausea, based on 12,671 FDA adverse event reports from 2004 to 2025. 9.0% of reports found the drug to be ineffective.

Liothyronine side effects

Percentages show how often each reaction appears relative to total reports for liothyronine.

1
Drug Ineffective9.0%1,139
2
Fatigue8.8%1,119
3
Headache8.5%1,074
4
Nausea6.4%810
5
Dyspnoea5.0%638
6
Pain4.9%616
7
Off Label Use4.8%603
8
Diarrhoea4.3%539
9
Malaise4.3%539
10
Hypertension4.0%507
11
Dizziness3.9%496
12
Weight Increased3.9%490
13
Feeling Abnormal3.8%483
14
Arthralgia3.7%463
15
Hypothyroidism3.6%462

These are voluntary reports and do not establish that liothyronine caused these reactions.

Report severity

47.5%Serious6,025 reports
17.9%Hospitalizations2,264 reports
2.8%Fatal352 reports

Seriousness is determined by the reporter, not by OpenClaim.

Liothyronine drug interactions

Other drugs that appear in adverse event reports alongside liothyronine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Levothyroxine-sodium11.5%1,461
2
Sodium-oxybate7.3%930
3
Bupropion3.0%374
4
Adalimumab2.7%344
5
Prednisone2.7%344
6
Apixaban2.6%327
7
Tramadol-hydrochloride2.2%285
8
Albuterol2.2%281
9
Clonazepam2.2%276
10
Metoprolol2.2%275
11
Spironolactone2.2%273
12
Trazodone-hydrochloride2.1%261
13
Montelukast-sodium2.0%256
14
Mometasone-furoate2.0%250
15
Cyanocobalamin1.9%244

Taken alongside

1
Levothyroxine-sodium54.6%6,923
2
Ergocalciferol19.7%2,491
3
Acetaminophen12.8%1,617
4
Albuterol10.2%1,289
5
Gabapentin9.4%1,197
6
Aspirin9.4%1,188
7
Omeprazole8.3%1,054
8
Fluticasone8.0%1,009
9
Cyanocobalamin7.8%989
10
Metformin7.2%906
11
Bupropion7.0%889
12
Montelukast-sodium7.0%887
13
Calcium6.9%873
14
Metoprolol6.4%812
15
Duloxetine-hydrochloride6.1%777

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports liothyronine side effects

79.6% of liothyronine adverse event reports involve female patients and 11.0% involve male patients. The largest age group is adult at 69%. These figures reflect who reports side effects, not underlying risk.

Sex

Female79.6%
Male11.0%
Unknown9.4%

Age group

< 20.3%
2–110.4%
12–170.4%
18–6469.2%
65+29.7%

What is liothyronine used for

Conditions and purposes for which patients were taking liothyronine when the adverse event was reported.

Addison^s DiseaseAdrenal InsufficiencyAffective DisorderAmnesiaAntidepressant TherapyAnxietyAstheniaAsthmaAutoimmune DisorderAutoimmune HypothyroidismAutoimmune ThyroiditisAccidental Exposure To ProductAdrenal InsufficiencyAdverse Drug ReactionAffective Disorder

Showing 15 of 241 indications

Liothyronine brand names and reporting trend

Liothyronine is sold under the brand name Triostat.

Brand names

Triostat8,259

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking liothyronine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.