OpenClaim

Linezolid Side Effects

The most commonly reported side effects of linezolid include off label use, thrombocytopenia, and anaemia, based on 30,849 FDA adverse event reports from 2004 to 2025. 6.1% of reports found the drug to be ineffective.

Linezolid side effects

Percentages show how often each reaction appears relative to total reports for linezolid.

1
Off Label Use8.2%2,525
2
Drug Ineffective6.1%1,894
3
Thrombocytopenia6.1%1,886
4
Anaemia5.1%1,584
5
Drug Interaction3.9%1,188
6
Nausea3.6%1,124
7
Acute Kidney Injury3.2%986
8
Vomiting3.1%941
9
Lactic Acidosis2.9%908
10
Pyrexia2.8%878
11
Diarrhoea2.8%878
12
Neuropathy Peripheral2.7%843
13
Pancytopenia2.5%760
14
Platelet Count Decreased2.4%743
15
Drug Resistance2.3%716

These are voluntary reports and do not establish that linezolid caused these reactions.

Report severity

91.3%Serious28,170 reports
42.9%Hospitalizations13,240 reports
18.4%Fatal5,666 reports

Seriousness is determined by the reporter, not by OpenClaim.

Linezolid drug interactions

Other drugs that appear in adverse event reports alongside linezolid. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Bedaquiline-fumarate8.8%2,723
2
Clofazimine8.2%2,528
3
Meropenem7.0%2,171
4
Vancomycin6.5%2,006
5
Moxifloxacin-hydrochloride6.0%1,862
6
Levofloxacin5.8%1,803
7
Amikacin-sulfate4.9%1,500
8
Pyrazinamide4.1%1,268
9
Ciprofloxacin3.9%1,203
10
Imipenem3.7%1,150
11
Cycloserine3.6%1,120
12
Daptomycin3.6%1,098
13
Azithromycin2.8%862
14
Ethambutol-hydrochloride2.8%853
15
Ceftriaxone-sodium2.6%803

Taken alongside

1
Meropenem8.4%2,577
2
Acetaminophen7.0%2,151
3
Furosemide6.7%2,058
4
Vancomycin6.0%1,842
5
Omeprazole5.1%1,578
6
Pantoprazole-sodium4.6%1,418
7
Levofloxacin4.3%1,328
8
Insulin4.2%1,301
9
Ciprofloxacin3.9%1,189
10
Amikacin-sulfate3.7%1,144
11
Fluconazole3.7%1,139
12
Aspirin3.7%1,138
13
Prednisone3.6%1,125
14
Albuterol3.5%1,090
15
Ondansetron3.3%1,003

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports linezolid side effects

38.5% of linezolid adverse event reports involve female patients and 49.7% involve male patients. The largest age group is adult at 55%. These figures reflect who reports side effects, not underlying risk.

Sex

Female38.5%
Male49.7%
Unknown11.9%

Age group

< 21.6%
2–113.0%
12–172.7%
18–6454.8%
65+37.8%

What is linezolid used for

Conditions and purposes for which patients were taking linezolid when the adverse event was reported.

Abdominal AbscessAbdominal DiscomfortAbdominal InfectionAbdominal PainAbdominal SepsisAbdominal Wall AbscessAbdominal Wall InfectionAbnormal FaecesAbscessAbscess BacterialAbscess DrainageAbscess JawAbscess LimbAbscess NeckAcanthamoeba Keratitis

Showing 15 of 1,364 indications

Linezolid brand names and reporting trend

Linezolid is sold under the brand name Zyvox.

Brand names

Zyvox28,722

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking linezolid with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.