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Levorphanol Side Effects

The most commonly reported side effects of levorphanol include pain, product dose omission issue, and nausea, based on 488 FDA adverse event reports from 2004 to 2025. 7.8% of reports found the drug to be ineffective.

Levorphanol side effects

Percentages show how often each reaction appears relative to total reports for levorphanol.

1
Pain8.2%40
2
Product Dose Omission Issue8.2%40
3
Drug Ineffective7.8%38
4
Nausea7.4%36
5
Product Dose Omission4.7%23
6
Headache4.1%20
7
Drug Dependence3.9%19
8
Anxiety3.5%17
9
Vomiting3.3%16
10
Diarrhoea3.3%16
11
Pruritus3.1%15
12
Dizziness2.9%14
13
Hyperhidrosis2.9%14
14
Product Availability Issue2.9%14
15
Insomnia2.7%13

These are voluntary reports and do not establish that levorphanol caused these reactions.

Report severity

33.4%Serious163 reports
12.7%Hospitalizations62 reports
7.2%Fatal35 reports

Seriousness is determined by the reporter, not by OpenClaim.

Levorphanol drug interactions

Other drugs that appear in adverse event reports alongside levorphanol. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Oxycodone6.1%30
2
Fentanyl5.7%28
3
Acetaminophen4.7%23
4
Sodium-oxybate4.5%22
5
Hydrocodone4.3%21
6
Hydromorphone-hydrochloride4.3%21
7
Tramadol-hydrochloride3.3%16
8
Morphine-sulfate2.9%14
9
Buprenorphine2.7%13
10
Methadone-hydrochloride2.5%12
11
Lenalidomide2.0%10
12
Oxymorphone-hydrochloride2.0%10
13
Dextromethorphan1.8%9
14
Apomorphine-hydrochloride1.8%9
15
Meperidine-hydrochloride1.8%9

Taken alongside

1
Gabapentin8.2%40
2
Oxycodone8.0%39
3
Ergocalciferol7.6%37
4
Acetaminophen7.2%35
5
Levothyroxine-sodium5.9%29
6
Pregabalin5.5%27
7
Diazepam5.3%26
8
Hydromorphone-hydrochloride5.1%25
9
Clonazepam5.1%25
10
Atorvastatin-calcium4.9%24
11
Aspirin4.7%23
12
Modafinil4.7%23
13
Albuterol4.5%22
14
Alprazolam4.5%22
15
Bupropion4.3%21

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports levorphanol side effects

61.1% of levorphanol adverse event reports involve female patients and 30.9% involve male patients. The largest age group is adult at 65%. These figures reflect who reports side effects, not underlying risk.

Sex

Female61.1%
Male30.9%
Unknown8.0%

Age group

< 23.6%
2–110.0%
12–170.6%
18–6464.7%
65+31.1%

What is levorphanol used for

Conditions and purposes for which patients were taking levorphanol when the adverse event was reported.

Abdominal PainAccident At WorkAnalgesic Intervention Supportive TherapyAnkylosing SpondylitisArthralgiaArthritisArthrodesisArthropathyAnalgesic TherapyBack PainBipolar DisorderBone PainBreakthrough PainCancer PainCervical Radiculopathy

Showing 15 of 75 indications

Levorphanol brand names and reporting trend

Levorphanol is sold under the brand name Levorphanol Tartrate.

Brand names

Levorphanol Tartrate4

Quarterly reports (20042025)

2004201020202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking levorphanol with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.