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Levopropoxyphene Side Effects

The most commonly reported side effects of levopropoxyphene include chronic kidney disease, renal failure, and acute kidney injury, based on 110 FDA adverse event reports from 2004 to 2023. 5.5% of reports found the drug to be ineffective.

Levopropoxyphene side effects

Percentages show how often each reaction appears relative to total reports for levopropoxyphene.

1
Chronic Kidney Disease14.5%16
2
Renal Failure13.6%15
3
Acute Kidney Injury10.9%12
4
End Stage Renal Disease10.0%11
5
Nephrogenic Anaemia7.3%8
6
Anaemia6.4%7
7
Headache6.4%7
8
Drug Ineffective5.5%6
9
Asthenia5.5%6
10
Confusional State5.5%6
11
Decreased Appetite5.5%6
12
Nausea5.5%6
13
Hyperparathyroidism Secondary5.5%6
14
Dizziness4.5%5
15
Pain In Extremity4.5%5

These are voluntary reports and do not establish that levopropoxyphene caused these reactions.

Report severity

79.1%Serious87 reports
34.5%Hospitalizations38 reports
20.0%Fatal22 reports

Seriousness is determined by the reporter, not by OpenClaim.

Levopropoxyphene drug interactions

Other drugs that appear in adverse event reports alongside levopropoxyphene. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Esomeprazole19.1%21
2
Pantoprazole-sodium13.6%15
3
Omeprazole10.0%11
4
Infliximab8.2%9
5
Digoxin8.2%9
6
Lansoprazole8.2%9
7
Adalimumab5.5%6
8
Quetiapine-fumarate5.5%6
9
Rabeprazole-sodium3.6%4
10
Dexlansoprazole3.6%4
11
Rosuvastatin2.7%3
12
Fentanyl1.8%2
13
Tadalafil1.8%2
14
Exenatide-synthetic1.8%2
15
Oxycodone1.8%2

Taken alongside

1
Acetaminophen32.7%36
2
Furosemide25.5%28
3
Ibuprofen24.5%27
4
Hydrocodone22.7%25
5
Prednisone21.8%24
6
Tramadol-hydrochloride21.8%24
7
Amlodipine19.1%21
8
Metoprolol19.1%21
9
Gabapentin17.3%19
10
Aspirin17.3%19
11
Azithromycin17.3%19
12
Cyclobenzaprine-hydrochloride16.4%18
13
Potassium-chloride14.5%16
14
Hydrochlorothiazide14.5%16
15
Ranitidine14.5%16

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports levopropoxyphene side effects

71.8% of levopropoxyphene adverse event reports involve female patients and 27.3% involve male patients. The largest age group is adult at 57%. These figures reflect who reports side effects, not underlying risk.

Sex

Female71.8%
Male27.3%
Unknown0.9%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6457.0%
65+43.0%

What is levopropoxyphene used for

Conditions and purposes for which patients were taking levopropoxyphene when the adverse event was reported.

Analgesic TherapyBlood Cholesterol AbnormalLocal AnaesthesiaMental DisorderPainProduct Used For Unknown IndicationPainProduct Used For Unknown IndicationSurgery

Levopropoxyphene brand names and reporting trend

Levopropoxyphene is sold under the brand name Novrad.

Brand names

Novrad112

Quarterly reports (20042023)

2005201020202023

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking levopropoxyphene with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.