OpenClaim

Levomilnacipran Side Effects

The most commonly reported side effects of levomilnacipran include off label use, vomiting, and gastrooesophageal reflux disease, based on 2,413 FDA adverse event reports from 2005 to 2025. 17.2% of reports found the drug to be ineffective.

Levomilnacipran side effects

Percentages show how often each reaction appears relative to total reports for levomilnacipran.

1
Off Label Use18.9%455
2
Drug Ineffective17.2%415
3
Vomiting14.8%357
4
Gastrooesophageal Reflux Disease14.5%351
5
Pain14.4%347
6
Paraesthesia13.7%330
7
Hypoaesthesia13.6%329
8
Abdominal Pain Upper13.6%329
9
Memory Impairment13.6%327
10
Taste Disorder12.9%312
11
Blepharospasm12.8%310
12
Drug Intolerance12.6%305
13
Epilepsy12.4%299
14
Nausea10.9%263
15
Depression10.7%259

These are voluntary reports and do not establish that levomilnacipran caused these reactions.

Report severity

62.1%Serious1,499 reports
25.5%Hospitalizations615 reports
20.2%Fatal487 reports

Seriousness is determined by the reporter, not by OpenClaim.

Levomilnacipran drug interactions

Other drugs that appear in adverse event reports alongside levomilnacipran. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Lamotrigine22.3%537
2
Naproxen20.8%503
3
Topiramate20.7%500
4
Erenumab-aooe20.6%496
5
Mirabegron20.5%495
6
Buprenorphine20.1%485
7
Pantoprazole-sodium20.1%485
8
Cetirizine-hydrochloride19.8%478
9
Azelaic-acid19.7%476
10
Betamethasone19.6%474
11
Ranitidine19.4%469
12
Cyclobenzaprine-hydrochloride19.4%469
13
Candesartan-cilexetil19.4%469
14
Atomoxetine-hydrochloride19.2%464
15
Hydromorphone-hydrochloride19.1%462

Taken alongside

1
Acetaminophen14.7%355
2
Ergocalciferol13.6%328
3
Lorazepam10.2%246
4
Clonazepam9.6%232
5
Levothyroxine-sodium9.5%229
6
Gabapentin9.2%223
7
Lisinopril9.0%218
8
Lamotrigine8.4%203
9
Pantoprazole-sodium8.2%197
10
Trazodone-hydrochloride7.8%189
11
Oxycodone7.3%176
12
Albuterol7.0%168
13
Tramadol-hydrochloride6.7%162
14
Dextroamphetamine6.6%159
15
Ibuprofen6.5%158

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports levomilnacipran side effects

71.9% of levomilnacipran adverse event reports involve female patients and 19.4% involve male patients. The largest age group is adult at 83%. These figures reflect who reports side effects, not underlying risk.

Sex

Female71.9%
Male19.4%
Unknown8.7%

Age group

< 20.5%
2–110.1%
12–171.6%
18–6483.3%
65+14.5%

What is levomilnacipran used for

Conditions and purposes for which patients were taking levomilnacipran when the adverse event was reported.

Adjuvant TherapyAffective DisorderAggressionAngerAntidepressant TherapyAnxietyAnxiety DisorderAstheniaAttention Deficit/hyperactivity DisorderAffective DisorderAntidepressant TherapyAnxietyAnxiety DisorderBipolar DisorderBipolar I Disorder

Showing 15 of 66 indications

Levomilnacipran brand names and reporting trend

Levomilnacipran is sold under brand names including Levomilnacipran, Levomilnacipran Hydrochloride.

Brand names

Levomilnacipran650
Levomilnacipran Hydrochloride33

Quarterly reports (20052025)

2005201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking levomilnacipran with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.