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Levomepromazine Side Effects

The most commonly reported side effects of levomepromazine include drug interaction, toxicity to various agents, and off label use, based on 5,315 FDA adverse event reports from 2004 to 2025. 7.5% of reports found the drug to be ineffective.

Levomepromazine side effects

Percentages show how often each reaction appears relative to total reports for levomepromazine.

1
Drug Interaction7.7%407
2
Drug Ineffective7.5%399
3
Toxicity To Various Agents7.0%374
4
Off Label Use6.8%360
5
Somnolence5.0%267
6
Vomiting4.9%263
7
Suicide Attempt4.4%233
8
Drug Abuse4.0%210
9
Nausea3.8%203
10
Pyrexia3.5%186
11
Hypotension3.4%181
12
Intentional Overdose3.4%180
13
Condition Aggravated3.3%173
14
Fatigue3.2%169
15
Diarrhoea3.2%168

These are voluntary reports and do not establish that levomepromazine caused these reactions.

Report severity

99.0%Serious5,262 reports
53.1%Hospitalizations2,823 reports
20.3%Fatal1,079 reports

Seriousness is determined by the reporter, not by OpenClaim.

Levomepromazine drug interactions

Other drugs that appear in adverse event reports alongside levomepromazine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Risperidone15.5%824
2
Olanzapine14.5%772
3
Quetiapine-fumarate14.0%746
4
Haloperidol10.2%543
5
Aripiprazole10.0%529
6
Diazepam7.8%413
7
Mirtazapine7.0%371
8
Clozapine6.1%322
9
Lorazepam5.7%305
10
Venlafaxine5.5%292
11
Clonazepam4.7%250
12
Eszopiclone4.7%250
13
Lamotrigine4.4%233
14
Paroxetine4.3%230
15
Valproate-sodium4.3%230

Taken alongside

1
Acetaminophen13.0%690
2
Lorazepam8.4%445
3
Ondansetron8.1%433
4
Omeprazole7.2%381
5
Haloperidol7.0%372
6
Dexamethasone6.7%355
7
Metoclopramide-hydrochloride6.2%331
8
Midazolam5.4%288
9
Lansoprazole5.2%279
10
Eszopiclone5.2%277
11
Morphine-sulfate5.1%269
12
Quetiapine-fumarate5.1%269
13
Diazepam4.8%256
14
Risperidone4.6%243
15
Cyclizine-lactate4.4%235

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports levomepromazine side effects

44.4% of levomepromazine adverse event reports involve female patients and 45.7% involve male patients. The largest age group is adult at 72%. These figures reflect who reports side effects, not underlying risk.

Sex

Female44.4%
Male45.7%
Unknown9.9%

Age group

< 20.6%
2–112.3%
12–174.7%
18–6472.2%
65+20.1%

What is levomepromazine used for

Conditions and purposes for which patients were taking levomepromazine when the adverse event was reported.

Abdominal PainAbnormal BehaviourAccidental ExposureAccidental Exposure To ProductAffect LabilityAffective DisorderAggressionAgitationAlcoholismAnalgesic TherapyAnkle FractureAntibiotic TherapyAntidepressant TherapyAntiemetic Supportive CareAntipsychotic Drug Level

Showing 15 of 259 indications

Levomepromazine brand names and reporting trend

Levomepromazine is sold under the brand name Levoprome.

Brand names

Levoprome6,400

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking levomepromazine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.