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Levomefolate Side Effects

The most commonly reported side effects of levomefolate include pulmonary embolism, pain, and deep vein thrombosis, based on 4,559 FDA adverse event reports from 2004 to 2025. 3.0% of reports found the drug to be ineffective.

Levomefolate side effects

Percentages show how often each reaction appears relative to total reports for levomefolate.

1
Pulmonary Embolism6.6%299
2
Pain6.3%286
3
Deep Vein Thrombosis5.6%256
4
Injury5.5%252
5
Foetal Exposure During Pregnancy4.7%214
6
Anxiety4.2%192
7
Emotional Distress3.9%180
8
Fatigue3.9%180
9
Off Label Use3.5%160
10
Dyspnoea3.3%152
11
Nausea3.1%142
12
Drug Ineffective3.0%135
13
Headache2.9%132
14
Drug Dose Omission2.7%124
15
Diarrhoea2.5%115

These are voluntary reports and do not establish that levomefolate caused these reactions.

Report severity

66.8%Serious3,047 reports
33.2%Hospitalizations1,515 reports
7.1%Fatal325 reports

Seriousness is determined by the reporter, not by OpenClaim.

Levomefolate drug interactions

Other drugs that appear in adverse event reports alongside levomefolate. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Ethinyl-estradiol34.9%1,593
2
Drospirenone34.9%1,590
3
Methotrexate4.3%197
4
Lamivudine3.7%169
5
Adalimumab3.5%160
6
Ulipristal-acetate3.1%140
7
Infliximab2.8%128
8
Sodium-oxybate2.5%113
9
Tenofovir2.1%94
10
Prednisone1.9%85
11
Eculizumab1.8%84
12
Etanercept1.6%75
13
Zidovudine1.5%68
14
Lenalidomide1.5%68
15
Dolutegravir1.5%68

Taken alongside

1
Ergocalciferol12.5%572
2
Acetaminophen11.0%502
3
Aspirin9.3%425
4
Cyanocobalamin9.2%420
5
Methotrexate7.9%360
6
Prednisone7.7%351
7
Levothyroxine-sodium7.7%349
8
Omeprazole6.6%301
9
Calcium6.3%288
10
Ethinyl-estradiol6.3%288
11
Albuterol5.7%261
12
Drospirenone5.6%257
13
Ibuprofen5.6%254
14
Furosemide5.3%242
15
Metoprolol5.1%231

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports levomefolate side effects

74.7% of levomefolate adverse event reports involve female patients and 20.9% involve male patients. The largest age group is adult at 71%. These figures reflect who reports side effects, not underlying risk.

Sex

Female74.7%
Male20.9%
Unknown4.3%

Age group

< 25.0%
2–110.8%
12–173.4%
18–6470.5%
65+20.3%

What is levomefolate used for

Conditions and purposes for which patients were taking levomefolate when the adverse event was reported.

Abdominal PainAbdominal Pain LowerAbdominal Pain UpperAbortion SpontaneousAcneAcne CysticAdverse EventAffective DisorderAlcohol UseAlcoholismAlopeciaAnaemiaAnaemia ProphylaxisAnkylosing SpondylitisAnxiety

Showing 15 of 182 indications

Levomefolate brand names and reporting trend

Levomefolate is sold under the brand name Tydemy.

Brand names

Tydemy2,796

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking levomefolate with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.