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Levofloxacin Side Effects

The most commonly reported side effects of levofloxacin include drug hypersensitivity, pain, and pneumonia, based on 100,822 FDA adverse event reports from 2004 to 2025. 3.6% of reports found the drug to be ineffective.

Levofloxacin side effects

Percentages show how often each reaction appears relative to total reports for levofloxacin.

1
Drug Hypersensitivity4.2%4,192
2
Pain4.0%4,078
3
Pneumonia4.0%4,038
4
Dyspnoea4.0%4,025
5
Off Label Use3.9%3,932
6
Fatigue3.9%3,931
7
Nausea3.9%3,918
8
Acute Kidney Injury3.7%3,760
9
Drug Ineffective3.6%3,658
10
Chronic Kidney Disease3.6%3,635
11
Arthralgia3.6%3,615
12
Diarrhoea3.3%3,332
13
Pyrexia3.3%3,288
14
Neuropathy Peripheral3.2%3,254
15
Pain In Extremity3.1%3,084

These are voluntary reports and do not establish that levofloxacin caused these reactions.

Report severity

84.4%Serious85,121 reports
41.4%Hospitalizations41,708 reports
11.7%Fatal11,771 reports

Seriousness is determined by the reporter, not by OpenClaim.

Levofloxacin drug interactions

Other drugs that appear in adverse event reports alongside levofloxacin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Omeprazole4.2%4,249
2
Lenalidomide4.0%4,012
3
Ciprofloxacin3.6%3,628
4
Pantoprazole-sodium3.4%3,400
5
Esomeprazole3.3%3,343
6
Prednisone3.2%3,191
7
Lansoprazole2.6%2,589
8
Venetoclax2.5%2,559
9
Dexamethasone2.4%2,457
10
Moxifloxacin-hydrochloride2.3%2,305
11
Linezolid2.1%2,143
12
Cyclophosphamide2.0%1,992
13
Vancomycin1.8%1,823
14
Amoxicillin1.7%1,702
15
Metronidazole1.7%1,673

Taken alongside

1
Acetaminophen15.6%15,729
2
Aspirin10.3%10,363
3
Furosemide10.2%10,252
4
Albuterol9.6%9,707
5
Acyclovir9.5%9,609
6
Prednisone9.4%9,427
7
Ondansetron8.6%8,641
8
Omeprazole7.8%7,869
9
Pantoprazole-sodium7.4%7,413
10
Ergocalciferol7.3%7,337
11
Amlodipine6.8%6,889
12
Levothyroxine-sodium6.8%6,855
13
Atorvastatin-calcium6.6%6,700
14
Metoprolol6.4%6,403
15
Gabapentin6.3%6,341

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports levofloxacin side effects

49.1% of levofloxacin adverse event reports involve female patients and 39.0% involve male patients. The largest age group is adult at 54%. These figures reflect who reports side effects, not underlying risk.

Sex

Female49.1%
Male39.0%
Unknown11.9%

Age group

< 20.4%
2–111.1%
12–171.1%
18–6454.0%
65+43.5%

What is levofloxacin used for

Conditions and purposes for which patients were taking levofloxacin when the adverse event was reported.

Abdominal AbscessAbdominal DiscomfortAbdominal InfectionAbdominal OperationAbdominal PainAbdominal Pain LowerAbdominal Pain UpperAbdominal SepsisAbnormal FaecesAbscessAbscess BacterialAbscess DrainageAbscess IntestinalAbscess LimbAcanthamoeba Keratitis

Showing 15 of 2,580 indications

Levofloxacin brand names and reporting trend

Levofloxacin is sold under the brand name Quixin.

Brand names

Quixin78,011

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking levofloxacin with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.