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Levodopa Side Effects

The most commonly reported side effects of levodopa include fall, death, and hallucination, based on 91,558 FDA adverse event reports from 2004 to 2025. 6.7% of reports found the drug to be ineffective.

Levodopa side effects

Percentages show how often each reaction appears relative to total reports for levodopa.

1
Fall9.0%8,280
2
Death7.7%7,090
3
Hallucination7.2%6,602
4
Drug Ineffective6.7%6,140
5
Dyskinesia6.2%5,650
6
Parkinson^s Disease5.7%5,181
7
Tremor5.1%4,685
8
Gait Disturbance3.9%3,611
9
Confusional State3.8%3,481
10
Dizziness3.8%3,461
11
Fatigue3.6%3,268
12
Nausea3.5%3,216
13
On And Off Phenomenon3.3%3,067
14
Somnolence3.2%2,909
15
Asthenia3.1%2,856

These are voluntary reports and do not establish that levodopa caused these reactions.

Report severity

68.5%Serious62,721 reports
35.2%Hospitalizations32,216 reports
17.0%Fatal15,551 reports

Seriousness is determined by the reporter, not by OpenClaim.

Levodopa drug interactions

Other drugs that appear in adverse event reports alongside levodopa. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Carbidopa50.0%45,777
2
Pimavanserin10.5%9,597
3
Entacapone5.8%5,323
4
Apomorphine-hydrochloride3.0%2,738
5
Amantadine2.4%2,177
6
Istradefylline2.2%2,016
7
Ropinirole-hydrochloride2.1%1,911
8
Rotigotine2.1%1,877
9
Pramipexole-dihydrochloride2.0%1,849
10
Rasagiline-mesylate1.7%1,562
11
Quetiapine-fumarate1.3%1,149
12
Clozapine1.0%927
13
Rivastigmine0.9%794
14
Droxidopa0.9%789
15
Mirtazapine0.5%488

Taken alongside

1
Carbidopa41.6%38,083
2
Aspirin9.6%8,823
3
Ergocalciferol7.7%7,076
4
Entacapone7.3%6,696
5
Amantadine7.0%6,452
6
Atorvastatin-calcium6.6%6,032
7
Quetiapine-fumarate6.6%6,002
8
Levothyroxine-sodium6.6%6,000
9
Acetaminophen6.4%5,905
10
Pramipexole-dihydrochloride5.8%5,299
11
Clonazepam5.7%5,237
12
Omeprazole5.6%5,162
13
Rasagiline-mesylate5.4%4,951
14
Gabapentin5.1%4,686
15
Ropinirole-hydrochloride5.0%4,602

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports levodopa side effects

40.4% of levodopa adverse event reports involve female patients and 53.4% involve male patients. The largest age group is elderly at 80%. These figures reflect who reports side effects, not underlying risk.

Sex

Female40.4%
Male53.4%
Unknown6.1%

Age group

< 2<0.1%
2–110.2%
12–170.2%
18–6419.3%
65+80.3%

What is levodopa used for

Conditions and purposes for which patients were taking levodopa when the adverse event was reported.

AbasiaAbnormal BehaviourAbnormal FaecesAccidental ExposureAccidental Exposure To ProductAccidental Exposure To Product By ChildAccidental OverdoseAdverse Drug ReactionAffective DisorderAgitationAkathisiaAkinesiaAltered State Of ConsciousnessAlzheimer^s DiseaseAnaemia

Showing 15 of 526 indications

Levodopa brand names and reporting trend

Levodopa is sold under the brand name Larodopa.

Brand names

Larodopa7,062

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking levodopa with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.