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Levocarnitine Side Effects

The most commonly reported side effects of levocarnitine include seizure, off label use, and vomiting, based on 4,520 FDA adverse event reports from 2004 to 2025. 4.7% of reports found the drug to be ineffective.

Levocarnitine side effects

Percentages show how often each reaction appears relative to total reports for levocarnitine.

1
Seizure9.0%408
2
Off Label Use7.1%323
3
Vomiting5.9%268
4
Diarrhoea5.6%251
5
Fatigue5.1%231
6
Drug Ineffective4.7%214
7
Pyrexia4.4%201
8
Pneumonia4.2%192
9
Nausea3.5%158
10
Decreased Appetite3.1%140
11
Somnolence3.1%139
12
Product Dose Omission Issue3.1%139
13
Death2.9%129
14
Dyspnoea2.6%116
15
Headache2.4%110

These are voluntary reports and do not establish that levocarnitine caused these reactions.

Report severity

77.5%Serious3,503 reports
45.3%Hospitalizations2,048 reports
10.6%Fatal478 reports

Seriousness is determined by the reporter, not by OpenClaim.

Levocarnitine drug interactions

Other drugs that appear in adverse event reports alongside levocarnitine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Cannabidiol7.6%345
2
Vigabatrin3.8%172
3
Stiripentol3.8%171
4
Fenfluramine3.5%160
5
Carglumic-acid3.5%157
6
Levetiracetam3.3%147
7
Sodium-oxybate3.3%147
8
Cysteamine3.1%141
9
Betaine2.8%128
10
Valproic-acid2.4%107
11
Clobazam2.4%107
12
Topiramate1.9%87
13
Somatropin1.8%81
14
Methotrexate1.7%76
15
Triheptanoin1.7%76

Taken alongside

1
Ergocalciferol18.1%819
2
Levetiracetam13.2%595
3
Acetaminophen12.4%559
4
Clobazam12.0%544
5
Diazepam10.0%453
6
Omeprazole9.8%445
7
Albuterol9.8%444
8
Levothyroxine-sodium9.5%431
9
Clonazepam9.1%412
10
Divalproex-sodium9.1%412
11
Aspirin7.8%351
12
Ondansetron7.7%349
13
Fluticasone7.4%333
14
Gabapentin7.0%317
15
Polyethylene-glycol-33506.9%312

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports levocarnitine side effects

42.3% of levocarnitine adverse event reports involve female patients and 41.1% involve male patients. The largest age group is adult at 39%. These figures reflect who reports side effects, not underlying risk.

Sex

Female42.3%
Male41.1%
Unknown16.6%

Age group

< 28.9%
2–1124.6%
12–1710.5%
18–6439.3%
65+16.7%

What is levocarnitine used for

Conditions and purposes for which patients were taking levocarnitine when the adverse event was reported.

Abdominal DiscomfortAcute Hepatic FailureAcute Kidney InjuryAcute Lymphocytic LeukaemiaAdiposis DolorosaAmino Acid Level AbnormalAmmonia AbnormalAmmonia IncreasedAnaemiaAntacid TherapyAntiemetic Supportive CareArginase DeficiencyAstheniaAzotaemiaAcidosis

Showing 15 of 299 indications

Levocarnitine brand names and reporting trend

Levocarnitine is sold under the brand name Levocarnitine Sf.

Brand names

Levocarnitine Sf4,341

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking levocarnitine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.