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Levobupivacaine Side Effects

The most commonly reported side effects of levobupivacaine include nausea, pain, and fatigue, based on 298 FDA adverse event reports from 2004 to 2025. 5.0% of reports found the drug to be ineffective.

Levobupivacaine side effects

Percentages show how often each reaction appears relative to total reports for levobupivacaine.

1
Nausea7.0%21
2
Pain5.4%16
3
Fatigue5.4%16
4
Drug Ineffective5.0%15
5
Pain In Extremity4.7%14
6
Malaise4.4%13
7
Headache4.4%13
8
Muscle Spasms4.0%12
9
Arthralgia4.0%12
10
Dyspnoea4.0%12
11
Paraesthesia3.7%11
12
Metabolic Alkalosis3.7%11
13
Confusion Postoperative3.7%11
14
Off Label Use3.4%10
15
Mental Status Changes Postoperative3.4%10

These are voluntary reports and do not establish that levobupivacaine caused these reactions.

Report severity

85.6%Serious255 reports
43.0%Hospitalizations128 reports
4.0%Fatal12 reports

Seriousness is determined by the reporter, not by OpenClaim.

Levobupivacaine drug interactions

Other drugs that appear in adverse event reports alongside levobupivacaine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Propofol13.4%40
2
Lidocaine12.1%36
3
Fentanyl10.4%31
4
Sufentanil-citrate8.4%25
5
Cefazolin-sodium7.4%22
6
Dexamethasone6.0%18
7
Paclitaxel5.4%16
8
Midazolam5.0%15
9
Letrozole5.0%15
10
Trastuzumab5.0%15
11
Sodium-chloride4.7%14
12
Cefuroxime4.7%14
13
Bupivacaine4.4%13
14
Ketamine-hydrochloride4.4%13
15
Ondansetron4.0%12

Taken alongside

1
Acetaminophen19.8%59
2
Ranitidine11.1%33
3
Omeprazole10.7%32
4
Ergocalciferol10.4%31
5
Dexamethasone10.1%30
6
Propofol9.4%28
7
Fish9.1%27
8
Ondansetron9.1%27
9
Aspirin8.7%26
10
Tranexamic-acid8.4%25
11
Fentanyl8.1%24
12
Oxycodone8.1%24
13
Lidocaine8.1%24
14
Sodium-chloride7.4%22
15
Folic-acid7.4%22

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports levobupivacaine side effects

60.7% of levobupivacaine adverse event reports involve female patients and 29.5% involve male patients. The largest age group is adult at 60%. These figures reflect who reports side effects, not underlying risk.

Sex

Female60.7%
Male29.5%
Unknown9.7%

Age group

< 23.2%
2–111.6%
12–173.2%
18–6459.9%
65+32.0%

What is levobupivacaine used for

Conditions and purposes for which patients were taking levobupivacaine when the adverse event was reported.

AdhesiolysisAnaesthesiaAnaesthetic PremedicationAnalgesic EffectAnalgesic TherapyArthrogramAnaesthesiaAnalgesic TherapyArthralgiaBack PainCatheter PlacementChest PainCoeliac DiseaseDrug Use For Unknown IndicationEpidural Anaesthesia

Showing 15 of 56 indications

Levobupivacaine brand names and reporting trend

Levobupivacaine is sold under the brand name Chirocaine.

Brand names

Chirocaine130

Quarterly reports (20042025)

20042010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking levobupivacaine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.