OpenClaim

Levetiracetam Side Effects

The most commonly reported side effects of levetiracetam include seizure, off label use, and fatigue, based on 133,930 FDA adverse event reports from 2004 to 2025. 8.7% of reports found the drug to be ineffective.

#1 Reported: SeizureAll side effects ↓Top Co-Medication: LacosamideDrug interactions ↓55% of Reports Are AdultDemographics ↓

Levetiracetam side effects

Percentages show how often each reaction appears relative to total reports for levetiracetam.

1
Seizure11.8%15,854
2
Drug Ineffective8.7%11,621
3
Off Label Use6.9%9,175
4
Fatigue3.7%4,972
5
Epilepsy3.0%4,063
6
Somnolence2.7%3,655
7
Maternal Exposure During Pregnancy2.6%3,488
8
Fall2.5%3,343
9
Headache2.4%3,229
10
Dizziness2.4%3,152
11
Nausea2.3%3,089
12
Drug Interaction2.3%3,066
13
Death2.3%3,056
14
Diarrhoea2.2%2,913
15
Foetal Exposure During Pregnancy2.2%2,909

These are voluntary reports and do not establish that levetiracetam caused these reactions.

Report severity

83.5%Serious111,786 reports
37.1%Hospitalizations49,679 reports
9.2%Fatal12,316 reports

Seriousness is determined by the reporter, not by OpenClaim.

Levetiracetam drug interactions

Other drugs that appear in adverse event reports alongside levetiracetam. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Lacosamide8.1%10,838
2
Lamotrigine6.2%8,345
3
Phenytoin4.1%5,556
4
Topiramate3.7%4,903
5
Valproic-acid3.6%4,788
6
Carbamazepine3.4%4,592
7
Clobazam3.3%4,445
8
Phenobarbital-sodium2.4%3,212
9
Vigabatrin2.2%3,006
10
Oxcarbazepine2.1%2,851
11
Valproate-sodium2.1%2,835
12
Clonazepam2.1%2,793
13
Midazolam1.9%2,585
14
Cannabidiol1.7%2,325
15
Zonisamide1.6%2,083

Taken alongside

1
Acetaminophen7.5%10,101
2
Lamotrigine5.4%7,233
3
Aspirin5.3%7,048
4
Levothyroxine-sodium5.1%6,831
5
Dexamethasone4.9%6,628
6
Omeprazole4.7%6,292
7
Ergocalciferol4.7%6,284
8
Gabapentin4.5%6,037
9
Pantoprazole-sodium4.5%5,968
10
Atorvastatin-calcium4.2%5,639
11
Lorazepam4.2%5,598
12
Ondansetron4.2%5,577
13
Amlodipine4.1%5,476
14
Clonazepam3.9%5,197
15
Furosemide3.8%5,147

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports levetiracetam side effects

47.4% of levetiracetam adverse event reports involve female patients and 39.5% involve male patients. The largest age group is adult at 55%. These figures reflect who reports side effects, not underlying risk.

Sex

Female47.4%
Male39.5%
Unknown13.2%

Age group

< 26.5%
2–119.2%
12–175.1%
18–6454.8%
65+24.4%

What is levetiracetam used for

Conditions and purposes for which patients were taking levetiracetam when the adverse event was reported.

Abnormal BehaviourAbnormal DreamsAbnormal EegAbnormal GaitAccidental ExposureAccidental Exposure To ProductAccidental Exposure To Product By ChildAccidental OverdoseAccidental PoisoningAcquired Epileptic AphasiaAcute Disseminated EncephalomyelitisAcute Encephalitis With Refractory, Repetitive Partial SeizuresAcute Haemorrhagic LeukoencephalitisAcute Lymphocytic LeukaemiaAcute Promyelocytic Leukaemia

Showing 15 of 1,472 indications

Levetiracetam brand names and reporting trend

Levetiracetam is sold under the brand name Keppra Xr.

Brand names

Keppra Xr95,351

Quarterly reports (2004–2025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking levetiracetam with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.

Check my medications