OpenClaim

Lesinurad Side Effects

The most commonly reported side effects of lesinurad include acute kidney injury, pain, and gout, based on 87 FDA adverse event reports from 2013 to 2022.

Lesinurad side effects

Percentages show how often each reaction appears relative to total reports for lesinurad.

1
Acute Kidney Injury16.1%14
2
Pain13.8%12
3
Gout11.5%10
4
Malaise11.5%10
5
Abdominal Pain11.5%10
6
Blood Creatinine Increased11.5%10
7
Nausea10.3%9
8
Flank Pain8.0%7
9
Renal Failure5.7%5
10
Rash4.6%4
11
Headache4.6%4
12
Circumstance Or Information Capable Of Leading To Medication Error4.6%4
13
Peripheral Swelling4.6%4
14
Diarrhoea4.6%4
15
Fatigue3.4%3

These are voluntary reports and do not establish that lesinurad caused these reactions.

Report severity

44.8%Serious39 reports
21.8%Hospitalizations19 reports
3.4%Fatal3 reports

Seriousness is determined by the reporter, not by OpenClaim.

Lesinurad drug interactions

Other drugs that appear in adverse event reports alongside lesinurad. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Allopurinol26.4%23
2
Diclofenac8.0%7
3
Colchicine6.9%6
4
Febuxostat5.7%5
5
Esomeprazole3.4%3
6
Lisinopril3.4%3
7
Omeprazole3.4%3
8
Naproxen2.3%2
9
Atenolol2.3%2
10
Ticagrelor2.3%2
11
Metoprolol1.1%1
12
Ruxolitinib1.1%1
13
Potassium-phosphate-monobasic1.1%1
14
Magnesium-acetate-tetrahydrate1.1%1
15
Lansoprazole1.1%1

Taken alongside

1
Febuxostat23.0%20
2
Allopurinol20.7%18
3
Colchicine17.2%15
4
Lisinopril9.2%8
5
Fenofibrate8.0%7
6
Aspirin6.9%6
7
Ibuprofen5.7%5
8
Amlodipine5.7%5
9
Cyanocobalamin5.7%5
10
Insulin5.7%5
11
Levothyroxine-sodium4.6%4
12
Pantoprazole-sodium4.6%4
13
Famotidine4.6%4
14
Fluticasone4.6%4
15
Furosemide3.4%3

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports lesinurad side effects

11.5% of lesinurad adverse event reports involve female patients and 62.1% involve male patients. The largest age group is adult at 78%. These figures reflect who reports side effects, not underlying risk.

Sex

Female11.5%
Male62.1%
Unknown26.4%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6478.4%
65+21.6%

What is lesinurad used for

Conditions and purposes for which patients were taking lesinurad when the adverse event was reported.

Blood Uric Acid AbnormalBlood Uric Acid IncreasedGoutGouty ArthritisGouty TophusHyperuricaemiaOff Label UseProduct Used For Unknown Indication

Lesinurad brand names and reporting trend

Lesinurad is sold under the brand name Duzallo.

Brand names

Duzallo15

Quarterly reports (20132022)

2013201620202022

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking lesinurad with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.