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Lenvatinib Side Effects

The most commonly reported side effects of lenvatinib include diarrhoea, hypertension, and fatigue, based on 36,666 FDA adverse event reports from 2013 to 2025.

Lenvatinib side effects

Percentages show how often each reaction appears relative to total reports for lenvatinib.

1
Diarrhoea12.3%4,522
2
Hypertension12.1%4,422
3
Fatigue10.4%3,810
4
Decreased Appetite9.3%3,420
5
Malignant Neoplasm Progression8.8%3,232
6
Nausea7.2%2,656
7
Blood Pressure Increased6.4%2,345
8
Vomiting5.7%2,081
9
Asthenia4.7%1,717
10
Malaise4.7%1,714
11
Weight Decreased4.4%1,615
12
Dehydration4.3%1,580
13
Pyrexia4.2%1,556
14
Hypothyroidism4.1%1,507
15
Headache3.6%1,332

These are voluntary reports and do not establish that lenvatinib caused these reactions.

Report severity

85.7%Serious31,411 reports
57.2%Hospitalizations20,977 reports
13.5%Fatal4,952 reports

Seriousness is determined by the reporter, not by OpenClaim.

Lenvatinib drug interactions

Other drugs that appear in adverse event reports alongside lenvatinib. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Pembrolizumab41.3%15,160
2
Everolimus7.5%2,748
3
Cabozantinib1.6%595
4
Belzutifan1.3%487
5
Bevacizumab1.0%378
6
Atezolizumab0.9%325
7
Oxaliplatin0.7%258
8
Amlodipine0.7%254
9
Nivolumab0.7%245
10
Carboplatin0.6%209
11
Tislelizumab-jsgr0.6%202
12
Fluorouracil0.5%179
13
Pemetrexed0.5%172
14
Toripalimab-tpzi0.5%168
15
Paclitaxel0.4%164

Taken alongside

1
Levothyroxine-sodium10.3%3,766
2
Pembrolizumab8.6%3,166
3
Amlodipine8.6%3,158
4
Acetaminophen5.6%2,059
5
Ondansetron3.7%1,360
6
Omeprazole3.3%1,195
7
Oxycodone2.9%1,053
8
Atorvastatin-calcium2.8%1,016
9
Aspirin2.7%987
10
Metformin2.6%971
11
Ergocalciferol2.6%971
12
Pantoprazole-sodium2.5%923
13
Metoprolol2.4%864
14
Furosemide2.3%850
15
Everolimus2.3%844

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports lenvatinib side effects

52.5% of lenvatinib adverse event reports involve female patients and 43.4% involve male patients. The largest age group is elderly at 60%. These figures reflect who reports side effects, not underlying risk.

Sex

Female52.5%
Male43.4%
Unknown4.2%

Age group

< 2<0.1%
2–110.1%
12–170.4%
18–6439.6%
65+59.8%

What is lenvatinib used for

Conditions and purposes for which patients were taking lenvatinib when the adverse event was reported.

AdenocarcinomaAdenocarcinoma GastricAdenocarcinoma PancreasAdenoid Cystic CarcinomaAdenoid Cystic Carcinoma Of Salivary GlandAdrenal Gland CancerAdrenal Gland Cancer MetastaticAdrenal MassAdrenal NeoplasmAdrenocortical CarcinomaAgranulocytosisAlveolar Soft Part SarcomaAmeloblastomaAnaplastic Thyroid CancerAbdominal Discomfort

Showing 15 of 660 indications

Lenvatinib brand names and reporting trend

Lenvatinib is sold under the brand name Lenvima.

Brand names

Lenvima2

Quarterly reports (20132025)

20132016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking lenvatinib with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.