OpenClaim

Lenalidomide Side Effects

The most commonly reported side effects of lenalidomide include diarrhoea, fatigue, and death, based on 416,345 FDA adverse event reports from 2005 to 2025.

#1 Reported: DiarrhoeaAll side effects ↓Top Co-Medication: DexamethasoneDrug interactions ↓71% of Reports Are ElderlyDemographics ↓

Lenalidomide side effects

Percentages show how often each reaction appears relative to total reports for lenalidomide.

1
Diarrhoea7.2%30,070
2
Fatigue6.1%25,262
3
Death5.3%22,165
4
Off Label Use4.4%18,220
5
Rash4.1%17,251
6
Plasma Cell Myeloma4.1%17,164
7
Pneumonia4.1%17,147
8
Neuropathy Peripheral2.8%11,516
9
White Blood Cell Count Decreased2.7%11,157
10
Constipation2.5%10,535
11
Nausea2.5%10,258
12
Asthenia2.2%9,262
13
Platelet Count Decreased2.1%8,783
14
Product Dose Omission Issue2.1%8,593
15
Neutropenia2.0%8,135

These are voluntary reports and do not establish that lenalidomide caused these reactions.

Report severity

64.7%Serious269,265 reports
26.3%Hospitalizations109,573 reports
12.7%Fatal53,056 reports

Seriousness is determined by the reporter, not by OpenClaim.

Lenalidomide drug interactions

Other drugs that appear in adverse event reports alongside lenalidomide. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Dexamethasone9.3%38,545
2
Bortezomib4.4%18,430
3
Daratumumab2.5%10,560
4
Ixazomib-citrate2.5%10,250
5
Carfilzomib1.9%7,849
6
Cyclophosphamide1.6%6,814
7
Pomalidomide1.4%6,021
8
Rituximab1.3%5,573
9
Doxorubicin-hydrochloride0.9%3,690
10
Prednisone0.8%3,424
11
Melphalan0.8%3,284
12
Thalidomide0.7%2,867
13
Vincristine-sulfate0.6%2,626
14
Isatuximab-irfc0.5%2,169
15
Elotuzumab0.5%2,142

Taken alongside

1
Dexamethasone16.2%67,406
2
Aspirin13.4%55,971
3
Acyclovir11.2%46,454
4
Acetaminophen7.0%28,939
5
Ergocalciferol5.9%24,747
6
Omeprazole5.2%21,485
7
Bortezomib4.6%19,347
8
Amlodipine4.6%19,327
9
Gabapentin4.6%19,273
10
Metoprolol4.3%18,100
11
Levothyroxine-sodium4.3%18,097
12
Atorvastatin-calcium4.2%17,354
13
Furosemide4.1%17,179
14
Ondansetron4.0%16,796
15
Calcium3.8%15,806

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports lenalidomide side effects

46.7% of lenalidomide adverse event reports involve female patients and 49.5% involve male patients. The largest age group is elderly at 71%. These figures reflect who reports side effects, not underlying risk.

Sex

Female46.7%
Male49.5%
Unknown3.8%

Age group

< 2<0.1%
2–11<0.1%
12–17<0.1%
18–6429.0%
65+70.9%

What is lenalidomide used for

Conditions and purposes for which patients were taking lenalidomide when the adverse event was reported.

5q Minus Mds5q Minus Myelodysplastic Syndrome5q Minus Syndrome5q-syndrome5q Minus SyndromeAbdominal DiscomfortAbdominal HerniaAbdominal LymphadenopathyAbdominal MassAbdominal PainAbnormal Loss Of WeightAccidental Exposure To ProductAcidosisAcquired HaemophiliaActinic Prurigo

Showing 15 of 1,887 indications

Lenalidomide brand names and reporting trend

Lenalidomide is sold under the brand name Lenalidomide.

Brand names

Lenalidomide79,763

Quarterly reports (2005–2025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking lenalidomide with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.

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