OpenClaim

Lenacapavir Side Effects

The most commonly reported side effects of lenacapavir include injection site discharge, injection site pain, and injection site nodule, based on 925 FDA adverse event reports from 2022 to 2025.

Lenacapavir side effects

Percentages show how often each reaction appears relative to total reports for lenacapavir.

1
Injection Site Discharge16.2%150
2
Injection Site Pain16.1%149
3
Injection Site Nodule14.8%137
4
Off Label Use14.6%135
5
Product Use Issue7.0%65
6
Labelled Drug-drug Interaction Medication Error6.5%60
7
Product Use In Unapproved Therapeutic Environment6.3%58
8
Injection Site Mass5.2%48
9
Injection Site Erythema4.9%45
10
Injection Site Swelling3.4%31
11
Nausea2.8%26
12
Viral Load Increased2.6%24
13
Fatigue2.6%24
14
Injection Site Reaction2.4%22
15
Death2.4%22

These are voluntary reports and do not establish that lenacapavir caused these reactions.

Report severity

23.1%Serious214 reports
6.9%Hospitalizations64 reports
4.4%Fatal41 reports

Seriousness is determined by the reporter, not by OpenClaim.

Lenacapavir drug interactions

Other drugs that appear in adverse event reports alongside lenacapavir. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Cabotegravir17.2%159
2
Rilpivirine14.5%134
3
Ibalizumab-uiyk5.1%47
4
Tenofovir3.9%36
5
Emtricitabine3.7%34
6
Dolutegravir2.3%21
7
Darunavir2.3%21
8
Ritonavir1.9%18
9
Fostemsavir-tromethamine1.3%12
10
Bictegravir1.3%12
11
Lamivudine1.2%11
12
Sacubitril0.8%7
13
Valsartan0.8%7
14
Cobicistat0.6%6
15
Doravirine0.6%6

Taken alongside

1
Tenofovir5.1%47
2
Emtricitabine4.5%42
3
Dolutegravir3.9%36
4
Ibalizumab-uiyk3.8%35
5
Cabotegravir3.7%34
6
Darunavir3.4%31
7
Fostemsavir-tromethamine2.9%27
8
Cobicistat2.2%20
9
Doravirine2.1%19
10
Aspirin2.1%19
11
Rilpivirine2.1%19
12
Albuterol1.7%16
13
Bictegravir1.5%14
14
Acyclovir1.4%13
15
Bupropion1.4%13

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports lenacapavir side effects

18.4% of lenacapavir adverse event reports involve female patients and 59.7% involve male patients. The largest age group is adult at 88%. These figures reflect who reports side effects, not underlying risk.

Sex

Female18.4%
Male59.7%
Unknown21.9%

Age group

< 21.2%
2–110.0%
12–170.0%
18–6488.0%
65+10.8%

What is lenacapavir used for

Conditions and purposes for which patients were taking lenacapavir when the adverse event was reported.

Acquired Immunodeficiency SyndromeAdverse Drug ReactionAntiretroviral TherapyExposure To Communicable DiseaseHiv InfectionHiv ViraemiaHiv-2 InfectionIntentional Self-injuryProduct Used For Unknown IndicationProphylaxisProphylaxis Against Hiv Infection

Lenacapavir brand names and reporting trend

Lenacapavir is sold under the brand name Yeztugo.

Brand names

Yeztugo739

Quarterly reports (20222025)

202220242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking lenacapavir with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.