OpenClaim

Lemborexant Side Effects

The most commonly reported side effects of lemborexant include off label use, suicide attempt, and somnolence, based on 2,438 FDA adverse event reports from 2019 to 2025. 11.7% of reports found the drug to be ineffective.

Lemborexant side effects

Percentages show how often each reaction appears relative to total reports for lemborexant.

1
Drug Ineffective11.7%286
2
Off Label Use6.8%165
3
Suicide Attempt5.5%133
4
Somnolence5.3%128
5
Condition Aggravated4.8%117
6
Suicidal Ideation4.7%115
7
Fall3.9%94
8
Headache3.4%84
9
Nausea3.4%83
10
Sleep Paralysis3.4%82
11
Dizziness3.2%77
12
Insomnia3.1%76
13
Nightmare3.0%74
14
Pyrexia2.9%71
15
Malaise2.7%67

These are voluntary reports and do not establish that lemborexant caused these reactions.

Report severity

75.5%Serious1,841 reports
44.1%Hospitalizations1,074 reports
11.1%Fatal270 reports

Seriousness is determined by the reporter, not by OpenClaim.

Lemborexant drug interactions

Other drugs that appear in adverse event reports alongside lemborexant. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Eszopiclone5.7%139
2
Brexpiprazole5.7%138
3
Vortioxetine5.4%131
4
Lurasidone-hydrochloride5.2%126
5
Quetiapine-fumarate5.1%125
6
Zolpidem-tartrate4.9%120
7
Risperidone4.8%118
8
Lorazepam4.7%115
9
Escitalopram-oxalate4.3%106
10
Gabapentin4.3%106
11
Mirtazapine4.1%101
12
Levomepromazine4.1%99
13
Apixaban4.1%99
14
Venlafaxine4.0%97
15
Lamotrigine3.9%94

Taken alongside

1
Magnesium-oxide11.8%288
2
Amlodipine10.5%256
3
Vonoprazan-fumarate8.2%199
4
Lansoprazole7.3%179
5
Ramelteon6.5%158
6
Trazodone-hydrochloride6.2%152
7
Acetaminophen5.5%134
8
Furosemide5.3%130
9
Rosuvastatin5.3%130
10
Aspirin5.3%129
11
Eszopiclone5.0%122
12
Quetiapine-fumarate4.8%117
13
Levothyroxine-sodium4.7%114
14
Bisoprolol-fumarate4.6%111
15
Zolpidem-tartrate4.5%109

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports lemborexant side effects

49.7% of lemborexant adverse event reports involve female patients and 39.5% involve male patients. The largest age group is elderly at 54%. These figures reflect who reports side effects, not underlying risk.

Sex

Female49.7%
Male39.5%
Unknown10.8%

Age group

< 20.4%
2–110.2%
12–170.6%
18–6444.6%
65+54.3%

What is lemborexant used for

Conditions and purposes for which patients were taking lemborexant when the adverse event was reported.

Abnormal BehaviourAccidental Exposure To Product By ChildAggressionAltered State Of ConsciousnessAnxiety DisorderAutonomic Nervous System ImbalanceBipolar DisorderCircadian Rhythm Sleep DisorderCognitive DisorderDelayed Sleep PhaseDeliriumDementiaDementia Alzheimer^s TypeDepressionDisease Complication

Showing 15 of 62 indications

Lemborexant brand names and reporting trend

Lemborexant is sold under the brand name Dayvigo.

Brand names

Dayvigo485

Quarterly reports (20192025)

2019202220242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking lemborexant with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.