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Lecanemab Side Effects

The most commonly reported side effects of lecanemab include headache, amyloid related imaging abnormality-oedema/effusion, and amyloid related imaging abnormality-microhaemorrhages and haemosiderin deposits, based on 3,038 FDA adverse event reports from 2015 to 2025.

Lecanemab side effects

Percentages show how often each reaction appears relative to total reports for lecanemab.

1
Headache14.3%433
2
Amyloid Related Imaging Abnormality-oedema/effusion13.4%406
3
Amyloid Related Imaging Abnormality-microhaemorrhages And Haemosiderin Deposits12.4%376
4
Infusion Related Reaction8.7%263
5
Chills7.3%223
6
Fatigue6.5%198
7
Pyrexia5.2%157
8
Confusional State5.0%152
9
Dizziness4.8%147
10
Nausea4.4%135
11
Cerebral Haemorrhage3.1%93
12
Fall2.9%87
13
Amyloid Related Imaging Abnormalities2.8%86
14
Vomiting2.7%81
15
Tremor2.6%80

These are voluntary reports and do not establish that lecanemab caused these reactions.

Report severity

38.9%Serious1,181 reports
23.0%Hospitalizations700 reports
4.1%Fatal125 reports

Seriousness is determined by the reporter, not by OpenClaim.

Lecanemab drug interactions

Other drugs that appear in adverse event reports alongside lecanemab. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Donepezil-hydrochloride0.6%18
2
Diphenhydramine0.5%14
3
Aspirin0.4%11
4
Acetaminophen0.4%11
5
Alteplase0.2%6
6
Sertraline-hydrochloride0.2%6
7
Atorvastatin-calcium0.2%6
8
Apixaban0.2%5
9
Levetiracetam0.2%5
10
Clopidogrel-bisulfate0.1%4
11
Losartan-potassium0.1%4
12
Gabapentin0.1%4
13
Memantine-hydrochloride0.1%4
14
Donanemab-azbt0.1%4
15
Gemfibrozil0.1%4

Taken alongside

1
Donepezil-hydrochloride10.9%330
2
Memantine-hydrochloride5.6%169
3
Aspirin4.9%149
4
Atorvastatin-calcium4.2%127
5
Amlodipine3.8%114
6
Rosuvastatin3.2%97
7
Levothyroxine-sodium2.8%85
8
Acetaminophen2.5%76
9
Ergocalciferol2.5%75
10
Lisinopril1.8%56
11
Cyanocobalamin1.8%56
12
Omeprazole1.8%55
13
Sertraline-hydrochloride1.8%54
14
Losartan-potassium1.7%53
15
Metoprolol1.7%52

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports lecanemab side effects

53.1% of lecanemab adverse event reports involve female patients and 37.3% involve male patients. The largest age group is elderly at 89%. These figures reflect who reports side effects, not underlying risk.

Sex

Female53.1%
Male37.3%
Unknown9.6%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6410.7%
65+89.3%

What is lecanemab used for

Conditions and purposes for which patients were taking lecanemab when the adverse event was reported.

AmnesiaCerebral Amyloid AngiopathyCerebrovascular AccidentCognitive DisorderDementia Alzheimer^s TypeDementiaDementia Alzheimer^s TypeDementia With Lewy BodiesMemory ImpairmentNormal Pressure HydrocephalusProduct Used For Unknown IndicationPositron Emission TomogramProduct Used For Unknown Indication

Lecanemab brand names and reporting trend

Lecanemab is sold under the brand name Leqembi Iqlik.

Brand names

Leqembi Iqlik374

Quarterly reports (20152025)

201520242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking lecanemab with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.