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Lebrikizumab Side Effects

The most commonly reported side effects of lebrikizumab include injection site pain, pruritus, and rash, based on 1,200 FDA adverse event reports from 2016 to 2025. 8.2% of reports found the drug to be ineffective.

Lebrikizumab side effects

Percentages show how often each reaction appears relative to total reports for lebrikizumab.

1
Injection Site Pain10.4%125
2
Pruritus9.0%108
3
Drug Ineffective8.2%98
4
Rash7.1%85
5
Conjunctivitis6.8%81
6
Dermatitis Atopic6.0%72
7
Eczema5.5%66
8
Erythema5.5%66
9
Urticaria3.0%36
10
Condition Aggravated3.0%36
11
Dry Skin2.8%34
12
Ocular Hyperaemia2.6%31
13
Hypersensitivity2.4%29
14
Eye Pruritus2.4%29
15
Incorrect Dose Administered2.2%26

These are voluntary reports and do not establish that lebrikizumab caused these reactions.

Report severity

16.1%Serious193 reports
5.0%Hospitalizations60 reports
0.5%Fatal6 reports

Seriousness is determined by the reporter, not by OpenClaim.

Lebrikizumab drug interactions

Other drugs that appear in adverse event reports alongside lebrikizumab. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Dupilumab12.5%150
2
Prednisone1.0%12
3
Omalizumab0.8%10
4
Montelukast-sodium0.8%9
5
Tiotropium-bromide0.8%9
6
Tralokinumab0.6%7
7
Upadacitinib0.6%7
8
Fluticasone0.5%6
9
Formoterol0.4%5
10
Cyclosporine0.3%3
11
Methotrexate0.3%3
12
Pirfenidone0.2%2
13
Abrocitinib0.2%2
14
Tirzepatide0.2%2
15
Deucravacitinib0.2%2

Taken alongside

1
Cetirizine-hydrochloride1.8%22
2
Ergocalciferol1.6%19
3
Triamcinolone1.4%17
4
Atorvastatin-calcium1.3%15
5
Clobetasol-propionate1.3%15
6
Levothyroxine-sodium1.1%13
7
Betamethasone1.1%13
8
Albuterol1.0%12
9
Tacrolimus0.9%11
10
Aspirin0.8%10
11
Amlodipine0.8%10
12
Ibuprofen0.8%10
13
Metronidazole0.8%10
14
Dupilumab0.8%10
15
Metoprolol0.8%10

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports lebrikizumab side effects

44.5% of lebrikizumab adverse event reports involve female patients and 33.9% involve male patients. The largest age group is adult at 67%. These figures reflect who reports side effects, not underlying risk.

Sex

Female44.5%
Male33.9%
Unknown21.6%

Age group

< 20.0%
2–110.7%
12–177.8%
18–6467.3%
65+24.1%

What is lebrikizumab used for

Conditions and purposes for which patients were taking lebrikizumab when the adverse event was reported.

AsthmaAdverse Drug ReactionAsthmaAtopyDermatitisDermatitis AtopicDermatitis ContactEczemaIdiopathic Pulmonary FibrosisInjection Site PruritusInjection Site RashNeurodermatitisPregnancyProduct Use In Unapproved IndicationProduct Used For Unknown Indication

Showing 15 of 20 indications

Lebrikizumab brand names and reporting trend

Lebrikizumab is sold under the brand name Ebglyss.

Brand names

Ebglyss125

Quarterly reports (20162025)

20162025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking lebrikizumab with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.