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Lazertinib Side Effects

The most commonly reported side effects of lazertinib include rash, infusion related reaction, and neuropathy peripheral, based on 460 FDA adverse event reports from 2012 to 2025.

Lazertinib side effects

Percentages show how often each reaction appears relative to total reports for lazertinib.

1
Rash20.2%93
2
Infusion Related Reaction10.2%47
3
Neuropathy Peripheral7.4%34
4
Fatigue6.7%31
5
Off Label Use5.4%25
6
Diarrhoea5.4%25
7
Paronychia5.0%23
8
Dyspnoea3.9%18
9
Nausea3.7%17
10
Pruritus3.5%16
11
Pneumonitis3.0%14
12
Oedema Peripheral2.8%13
13
Stomatitis2.8%13
14
Dizziness2.8%13
15
Decreased Appetite2.6%12

These are voluntary reports and do not establish that lazertinib caused these reactions.

Report severity

65.2%Serious300 reports
23.9%Hospitalizations110 reports
4.3%Fatal20 reports

Seriousness is determined by the reporter, not by OpenClaim.

Lazertinib drug interactions

Other drugs that appear in adverse event reports alongside lazertinib. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Amivantamab62.8%289
2
Osimertinib-mesylate3.0%14
3
Pemetrexed1.7%8
4
Carboplatin1.5%7
5
Rivaroxaban1.5%7
6
Doxycycline1.5%7
7
Tamsulosin-hydrochloride1.3%6
8
Alfuzosin-hydrochloride1.3%6
9
Bevacizumab1.3%6
10
Crizotinib1.1%5
11
Apixaban0.9%4
12
Afatinib0.4%2
13
Gefitinib0.4%2
14
Hyaluronidase0.4%2
15
Omalizumab0.2%1

Taken alongside

1
Apixaban9.3%43
2
Dexamethasone7.4%34
3
Ondansetron5.9%27
4
Acetaminophen5.4%25
5
Amivantamab3.9%18
6
Ergocalciferol3.9%18
7
Folic-acid3.5%16
8
Doxycycline3.5%16
9
Aspirin3.3%15
10
Furosemide3.3%15
11
Atorvastatin-calcium3.3%15
12
Metoprolol2.8%13
13
Amlodipine2.8%13
14
Rivaroxaban2.8%13
15
Oxycodone2.4%11

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports lazertinib side effects

44.6% of lazertinib adverse event reports involve female patients and 28.3% involve male patients. The largest age group is elderly at 57%. These figures reflect who reports side effects, not underlying risk.

Sex

Female44.6%
Male28.3%
Unknown27.2%

Age group

< 20.0%
2–110.4%
12–170.0%
18–6442.9%
65+56.7%

What is lazertinib used for

Conditions and purposes for which patients were taking lazertinib when the adverse event was reported.

Benign Lung NeoplasmBronchial CarcinomaEgfr Gene MutationHeadacheLung AdenocarcinomaLung Adenocarcinoma RecurrentLung Adenocarcinoma Stage IvLung Cancer MetastaticLung Carcinoma Cell Type Unspecified RecurrentLung Carcinoma Cell Type Unspecified Stage 0Lung Carcinoma Cell Type Unspecified Stage ILung Neoplasm MalignantMalignant Respiratory Tract NeoplasmNon-small Cell Lung CancerNeoplasm Malignant

Showing 15 of 20 indications

Lazertinib brand names and reporting trend

Lazertinib is sold under the brand name Lazcluze.

Brand names

Lazcluze261

Quarterly reports (20122025)

201220242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking lazertinib with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.