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Latanoprost Side Effects

The most commonly reported side effects of latanoprost include treatment failure, fatigue, and eye irritation, based on 51,039 FDA adverse event reports from 2004 to 2025. 5.5% of reports found the drug to be ineffective.

Latanoprost side effects

Percentages show how often each reaction appears relative to total reports for latanoprost.

1
Treatment Failure11.6%5,920
2
Drug Ineffective5.5%2,789
3
Fatigue4.0%2,045
4
Eye Irritation3.7%1,882
5
Off Label Use3.0%1,544
6
Headache3.0%1,513
7
Diarrhoea2.9%1,469
8
Death2.8%1,431
9
Eye Pain2.8%1,421
10
Dyspnoea2.6%1,328
11
Nausea2.6%1,305
12
Dizziness2.5%1,295
13
Vision Blurred2.5%1,283
14
Fall2.4%1,216
15
Ocular Hyperaemia2.1%1,092

These are voluntary reports and do not establish that latanoprost caused these reactions.

Report severity

54.5%Serious27,823 reports
20.6%Hospitalizations10,490 reports
6.3%Fatal3,226 reports

Seriousness is determined by the reporter, not by OpenClaim.

Latanoprost drug interactions

Other drugs that appear in adverse event reports alongside latanoprost. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Timolol6.8%3,467
2
Brimonidine-tartrate6.2%3,160
3
Bimatoprost4.2%2,125
4
Lenalidomide3.8%1,952
5
Dorzolamide-hydrochloride3.4%1,717
6
Brinzolamide2.8%1,450
7
Travoprost2.8%1,442
8
Adalimumab1.7%869
9
Netarsudil1.4%698
10
Cenegermin-bkbj1.2%612
11
Apixaban1.2%594
12
Omeprazole1.1%580
13
Dupilumab1.1%572
14
Atorvastatin-calcium1.1%558
15
Metformin1.0%531

Taken alongside

1
Aspirin14.3%7,296
2
Timolol12.5%6,390
3
Acetaminophen11.0%5,635
4
Ergocalciferol10.8%5,537
5
Atorvastatin-calcium10.8%5,531
6
Levothyroxine-sodium10.3%5,265
7
Amlodipine9.5%4,838
8
Furosemide8.7%4,424
9
Brimonidine-tartrate8.6%4,371
10
Omeprazole8.2%4,182
11
Metoprolol7.8%3,987
12
Dorzolamide-hydrochloride7.7%3,952
13
Albuterol7.1%3,600
14
Metformin6.4%3,255
15
Lisinopril6.3%3,192

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports latanoprost side effects

57.2% of latanoprost adverse event reports involve female patients and 36.4% involve male patients. The largest age group is elderly at 77%. These figures reflect who reports side effects, not underlying risk.

Sex

Female57.2%
Male36.4%
Unknown6.3%

Age group

< 20.1%
2–110.3%
12–170.3%
18–6422.8%
65+76.6%

What is latanoprost used for

Conditions and purposes for which patients were taking latanoprost when the adverse event was reported.

Abnormal Sensation In EyeAcanthamoeba KeratitisAdverse EventAge-related Macular DegenerationAnaesthesiaAngle Closure GlaucomaAngle Glaucoma ClosedAntibiotic ProphylaxisAstigmatismAtrial FibrillationAutoimmune RetinopathyAutoimmune UveitisAdverse Drug ReactionAge-related Macular DegenerationAngle Closure Glaucoma

Showing 15 of 305 indications

Latanoprost brand names and reporting trend

Latanoprost is sold under the brand name Xalatan.

Brand names

Xalatan34,763

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking latanoprost with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.