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Laronidase Side Effects

The most commonly reported side effects of laronidase include pyrexia, pneumonia, and malaise, based on 3,970 FDA adverse event reports from 2004 to 2025.

#1 Reported: PyrexiaAll side effects ↓Top Co-Medication: DiphenhydramineDrug interactions ↓40% of Reports Are ChildDemographics ↓

Laronidase side effects

Percentages show how often each reaction appears relative to total reports for laronidase.

1
Pyrexia11.3%447
2
Pneumonia4.8%189
3
Malaise4.5%177
4
Dyspnoea4.4%173
5
Vomiting4.3%170
6
Cough4.1%163
7
Fatigue3.5%140
8
Death3.0%121
9
Pain2.9%116
10
Influenza2.9%115
11
Condition Aggravated2.8%112
12
Inappropriate Schedule Of Product Administration2.8%111
13
Headache2.7%108
14
Nasopharyngitis2.4%97
15
Off Label Use2.3%92

These are voluntary reports and do not establish that laronidase caused these reactions.

Report severity

69.7%Serious2,769 reports
34.6%Hospitalizations1,375 reports
16.6%Fatal659 reports

Seriousness is determined by the reporter, not by OpenClaim.

Laronidase drug interactions

Other drugs that appear in adverse event reports alongside laronidase. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Diphenhydramine0.3%13
2
Acetaminophen0.2%7
3
Cyclosporine0.2%6
4
Warfarin0.1%5
5
Fentanyl0.1%4
6
Busulfan0.1%4
7
Levothyroxine-sodium0.1%4
8
Fludarabine-phosphate<0.1%3
9
Cyclophosphamide<0.1%3
10
Furosemide<0.1%3
11
Sulfamethoxazole<0.1%3
12
Sodium-chloride<0.1%3
13
Agalsidase-beta<0.1%3
14
Ivabradine<0.1%3
15
Levetiracetam<0.1%3

Taken alongside

1
Diphenhydramine10.7%426
2
Acetaminophen10.1%399
3
Epinephrine6.8%270
4
Heparin6.4%253
5
Sodium-chloride5.4%215
6
Albuterol4.0%158
7
Furosemide3.6%141
8
Ammonium3.6%141
9
Lidocaine3.4%135
10
Ibuprofen2.2%88
11
Enalapril-maleate2.1%85
12
Warfarin2.1%82
13
Prilocaine2.0%81
14
Ergocalciferol2.0%81
15
Cetirizine-hydrochloride2.0%80

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports laronidase side effects

36.2% of laronidase adverse event reports involve female patients and 36.5% involve male patients. The largest age group is child at 40%. These figures reflect who reports side effects, not underlying risk.

Sex

Female36.2%
Male36.5%
Unknown27.2%

Age group

< 211.4%
2–1139.7%
12–1716.3%
18–6432.5%
65+0.1%

What is laronidase used for

Conditions and purposes for which patients were taking laronidase when the adverse event was reported.

Amenorrhoea-galactorrhoea SyndromeComplement Factor AbnormalEnzyme SupplementationExposure During Breast FeedingGaucher^s DiseaseGlycogen Storage Disease Type IiGaucher^s DiseaseGlycogen Storage Disease Type IGlycogen Storage Disease Type IiImmunodeficiencyMaternal Exposure Timing UnspecifiedMucopolysaccharidosisMucopolysaccharidosis IMucopolysaccharidosis IhMucopolysaccharidosis Ih/s

Showing 15 of 29 indications

Laronidase brand names and reporting trend

Laronidase is sold under the brand name Aldurazyme.

Brand names

Aldurazyme1,082

Quarterly reports (2004–2025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking laronidase with another medication?

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