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Lansoprazole Side Effects

The most commonly reported side effects of lansoprazole include chronic kidney disease, acute kidney injury, and renal failure, based on 176,332 FDA adverse event reports from 2004 to 2025. 2.9% of reports found the drug to be ineffective.

Lansoprazole side effects

Percentages show how often each reaction appears relative to total reports for lansoprazole.

1
Chronic Kidney Disease18.6%32,827
2
Acute Kidney Injury10.6%18,754
3
Renal Failure7.5%13,204
4
End Stage Renal Disease5.6%9,798
5
Renal Injury5.4%9,447
6
Diarrhoea4.1%7,232
7
Off Label Use3.8%6,670
8
Nausea3.8%6,630
9
Dyspnoea3.6%6,313
10
Fatigue3.6%6,306
11
Vomiting3.1%5,498
12
Headache3.1%5,452
13
Pain3.1%5,439
14
Drug Ineffective2.9%5,135
15
Malaise2.8%4,943

These are voluntary reports and do not establish that lansoprazole caused these reactions.

Report severity

87.2%Serious153,780 reports
36.4%Hospitalizations64,169 reports
11.1%Fatal19,641 reports

Seriousness is determined by the reporter, not by OpenClaim.

Lansoprazole drug interactions

Other drugs that appear in adverse event reports alongside lansoprazole. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Omeprazole20.5%36,121
2
Esomeprazole18.6%32,802
3
Pantoprazole-sodium16.7%29,453
4
Dexlansoprazole10.2%18,074
5
Naproxen3.9%6,813
6
Rabeprazole-sodium3.7%6,519
7
Adalimumab3.4%6,079
8
Acetaminophen2.5%4,483
9
Methotrexate2.3%4,055
10
Prednisone2.3%4,051
11
Infliximab2.2%3,840
12
Rituximab2.1%3,791
13
Etanercept2.0%3,481
14
Atorvastatin-calcium1.9%3,279
15
Furosemide1.8%3,143

Taken alongside

1
Acetaminophen16.9%29,826
2
Aspirin14.6%25,675
3
Atorvastatin-calcium11.8%20,722
4
Furosemide11.7%20,684
5
Amlodipine10.2%17,905
6
Albuterol9.2%16,265
7
Levothyroxine-sodium9.2%16,179
8
Ergocalciferol7.6%13,487
9
Lisinopril7.3%12,826
10
Simvastatin6.6%11,698
11
Metformin6.6%11,643
12
Prednisone6.5%11,522
13
Gabapentin6.3%11,178
14
Ibuprofen6.1%10,749
15
Bisoprolol-fumarate6.0%10,649

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports lansoprazole side effects

48.7% of lansoprazole adverse event reports involve female patients and 34.8% involve male patients. The largest age group is adult at 48%. These figures reflect who reports side effects, not underlying risk.

Sex

Female48.7%
Male34.8%
Unknown16.5%

Age group

< 20.8%
2–111.8%
12–171.7%
18–6448.0%
65+47.7%

What is lansoprazole used for

Conditions and purposes for which patients were taking lansoprazole when the adverse event was reported.

Abdominal DiscomfortAbdominal DistensionAbdominal HerniaAbdominal OperationAbdominal PainAbdominal Pain UpperAbdominal RigidityAbdominal SymptomAbscessAccidental Exposure To ProductAccidental Exposure To Product By ChildAchlorhydriaAcid Base BalanceAcid Base Balance AbnormalAcid Peptic Disease

Showing 15 of 1,098 indications

Lansoprazole brand names and reporting trend

Lansoprazole is sold under the brand name Prevacid.

Brand names

Prevacid115,309

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking lansoprazole with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.