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Landiolol Side Effects

The most commonly reported side effects of landiolol include off label use, bradycardia, and pneumonia, based on 185 FDA adverse event reports from 2005 to 2025. 18.4% of reports found the drug to be ineffective.

#1 Reported: Off Label UseAll side effects ↓Top Co-Medication: Amiodarone-hydrochlorideDrug interactions ↓58% of Reports Are ElderlyDemographics ↓

Landiolol side effects

Percentages show how often each reaction appears relative to total reports for landiolol.

1
Drug Ineffective18.4%34
2
Off Label Use10.3%19
3
Bradycardia8.6%16
4
Pneumonia7.6%14
5
Cardiac Arrest5.9%11
6
Condition Aggravated4.9%9
7
Cardiac Failure4.3%8
8
Ventricular Fibrillation3.8%7
9
Multiple Organ Dysfunction Syndrome3.8%7
10
Blood Pressure Decreased3.2%6
11
Hypoxia3.2%6
12
Product Use In Unapproved Indication3.2%6
13
Sepsis3.2%6
14
Drug Ineffective For Unapproved Indication3.2%6
15
Stress Cardiomyopathy2.7%5

These are voluntary reports and do not establish that landiolol caused these reactions.

Report severity

98.9%Serious183 reports
54.6%Hospitalizations101 reports
31.9%Fatal59 reports

Seriousness is determined by the reporter, not by OpenClaim.

Landiolol drug interactions

Other drugs that appear in adverse event reports alongside landiolol. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Amiodarone-hydrochloride14.6%27
2
Hydrocortisone8.6%16
3
Bisoprolol-fumarate5.9%11
4
Meropenem5.4%10
5
Verapamil-hydrochloride5.4%10
6
Furosemide4.9%9
7
Lidocaine4.3%8
8
Heparin4.3%8
9
Acetaminophen4.3%8
10
Methimazole3.8%7
11
Prednisolone3.8%7
12
Tacrolimus3.8%7
13
Epinephrine3.8%7
14
Cefiderocol-sulfate-tosylate3.8%7
15
Propofol3.2%6

Taken alongside

1
Fentanyl18.9%35
2
Furosemide17.3%32
3
Epinephrine17.3%32
4
Bisoprolol-fumarate16.2%30
5
Propofol15.7%29
6
Hydrocortisone14.1%26
7
Insulin11.9%22
8
Acetaminophen11.9%22
9
Heparin11.4%21
10
Midazolam10.8%20
11
Dexmedetomidine-hydrochloride10.3%19
12
Meropenem10.3%19
13
Vancomycin9.7%18
14
Omeprazole9.2%17
15
Dobutamine-hydrochloride8.6%16

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports landiolol side effects

30.3% of landiolol adverse event reports involve female patients and 65.9% involve male patients. The largest age group is elderly at 58%. These figures reflect who reports side effects, not underlying risk.

Sex

Female30.3%
Male65.9%
Unknown3.8%

Age group

< 22.9%
2–112.9%
12–173.5%
18–6432.7%
65+57.9%

What is landiolol used for

Conditions and purposes for which patients were taking landiolol when the adverse event was reported.

Acute Myocardial InfarctionArrhythmiaArrhythmia ProphylaxisAtrial FibrillationAtrial TachycardiaArrhythmiaArrhythmic StormAtrial FibrillationAtrial FlutterAtrial TachycardiaAtrioventricular Block CompleteBlood Pressure DecreasedBasedow^s DiseaseCardiac FailureCardiac Failure Acute

Showing 15 of 55 indications

Landiolol brand names and reporting trend

Landiolol is sold under the brand name Rapiblyk.

Brand names

Rapiblyk212

Quarterly reports (2005–2025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking landiolol with another medication?

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